Archive for January, 2016

Becoming Species

“There is religion when the sacred is distinguished from the profane”

– Emile Durkheim

Humans resist states of being at the heart of evolution: separation, isolation, freakishness, outlying but new species are born of weirdness, cataclysm, getting lost, change, mutation of molecule, cell, body, local environment and ecosystem. When the Earth moves – animals and plants evolve.  Continuity and comfort means equilibrium, balance, regularity, harmony, sameness. Nature does not embrace change unless change is vital for survival. Our nucleic acids battle efforts to change them 24/7. Most of this DNA / RNA change is bad and almost all is edited out of the genome prior to inheritance.

A species is a group of organisms that interbreed. Robins don’t interbreed with cardinals thus- two different species. Japanese people can and do interbreed successfully with caucasians thus they are the same species. All humans are the same species and there is only a single one-Homo sapiens. There are over 800,000 species of beetles, 20,000 species of bony fish.

Species evolve when and if they must otherwise they do not evolve. Species maintain their equilibrium over eons. A mosquito of today is almost identical to a mosquito that pestered the dinosaurs. There has been no evidence that a single higher animal has evolved in any way since Darwin published “On the Origin of Species” in 1861. Evolution, when it happens, is almost always abrupt on a geological scale, intensely slow in human terms.

Niles Eldredge and Stephen Jay Gould proposed their theory of Punctuated Equilibrium in 1974 asserting multicell organisms ( non-bacteria, non-virus, non-archaea) evolve when confronted with large environmental change such as an ice or heat age, grand geologic shifts-new islands and continents forming, a meteor impact’s negative effect on the atmosphere. This punctuation may take ten million years to play out giving rise to new species then stasis returns to this species for 100 or 500 million years. The fossil record confirms punctuated equilibrium. Stasis is data. Darwin proposed that all organisms are evolving continuously. This has been proven false. Organisms may change with each new generation ( your face is different than that of your parent) but change is not evolution. Evolution implies change for the better. DNA has evolved for four billion years to resist change – to edit mutation away from its double helix before conception. There is evidence for evolution of plants and animals over the past 3.5 billion years but it has not been continuous and the evidence itself is not at all continuous.

Pathways to speciation are many. During the 1960s bioscientist Lynn Margulis proposed the symbiotic path to species evolution where two different species merge creating a new, more formidable species. When the single-cell energy engine mitochondria merged with other, less energetic single cell organisms three billion years ago many new species of microorganism emerged. When proto-organ systems merged many good things happened within an organism: fluids were synthesized, pumped, filtered, properly timed and the creature remembered where the food lived.  Mergers and acquisitions were ( are?)  a key pathway to speciation. Organisms under great pressure forced to merge with one another in shrinking crowded conditions miles below global ice sheets, speciation occurring next to warm vents from deep within the Earth’s mantle. Population pressure – creatures breaking into one another’s skin and happy with the result. More energy, more motility, more durability, bigger teeth.

Three pathways, of many, to evolution:

  1. Rolling the dice 1,000 times per hour under UV bombardment,  testing new combinations and features against all environments – intracell on up the hierarchy of systems out into the primordial ooze – the Darwin method: mutation followed by natural selection.
  2.  Accidents of fate, genetic drift,  a population disperses throughout the realm, those creatures most remote find themselves on a broken off piece of continent, a new island where they live for eons in isolation from their fellows. Their genes have drifted, initiating evolution of new species. Natural selection was not the primary cause.
  3.  Epigenetics – evolution occurs as DNA, RNA, histones, heritable proteins receive signals between every single cell division among 10 trillion cells throughout a higher organism’s reproductive years. Countless micro-events with evolutionary consequences at each cell division, once a week not at each lifetime. Evolution occurring as each cell divides not as each organism has more fit or less fit offspring. New information re: fitness relayed to the germline: eggs and sperm for inclusion in next year’s model. One thousand trillion evolutionary events per lifetime – not just an array of  random nucleotide mutations passed from parent to child. Non-stop evolutionary feedback-feedforward loops throughout trillions of moments in a single life.

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JB Questions and observations:

Reading: “Elementary Forms of Religious Life” – Emile Durkheim

  1. Is a television a totem? Does television fill a totemic role in American ( Western) culture?  How about a laptop or an I-phone or a car?
  2. Claude Levi-Strauss patterned his book “the Savage Mind” on Durkheim’s “The Elementary forms of Religious Life”. Both men used the same strategy of assembling published papers in anthropology-social science acting as clearing house for the ideas of many in neat, summaries that became foundational texts.
  3. Types of american totemism within our religion of Capitalism: a.infototems: TV,laptop, I-phone b.Utilitotem; Washer, dryer, range, refrigerator-freezer c. Statustotem: auto, espresso machine
  4. The quark as The God Particle is 100% totemism.
  5. ToDo: Reinstate animal / plant totemism in USA. Assign each animal and plant species in the world to groups of school children investing them with the responsibility to care for their totem organism throughout their lives.
  6. Why would one animal species select another species as a totem?
  7. Note:  Durkheim espousing contextuality in 1912. Contextuality didn’t hit the realm of the built environment ( City planning and architecture) until 1960 in the work of Jane Jacobs. Have architects EVER been on the cutting edge of the ideas of a given era? Not after the era of the Gothic cathedral.
  8. Did the thought of Ruskin and Morris have any direct effect upon Le Corbusier and Mies or was it always filtered through Frank Lloyd wright via the Wasmuth Portfolio? Can one get the full import of an idea second or third hand? That we can, forms the backbone of modern education.
  9. Architecture coughs up its Jencksian history hairball in the mid-1970s lame swerve on hardcore French Postmodernism in the work of Charles Moore, Michael Graves and other pasticheurs of the time. Ughh, such a superficial, desolate and highly publicized dead end for architecture – suckered again.
  10. If snowball Earth had an ice sheet 20 miles thick one billion years ago this must have had an additive effect upon mutational effects of UV radiation as warm pools at top of this high ice were exposed to sunlight at 20 miles up, beyond any filtering atmosphere. Did this high ice push exisitng atmosphere up with it or leave it behind?
  11. JB neologism: “Stochastic Targeting”: to send a barrage of speculative detail. Target mind adjusts this barrage with details known to recipient so it appears that you were 80% correct instead of shooting in the dark.
  12. Can a recessive gene become active during one’s lifespan if the dominant gene fails? How might an activated recessive gene attract RNA polymerase to begin midlife transcription? How does RNA polymerase know which is the dominant gene in the first place?
  13. Sewall Wright gets a lot of credit for adding to our knowledge of evolution as a key generator of the Modern synthesis that combined Darwinism with modern genetics. In retrospect, is this credit deserved?  Was Wright seeing evolution at work with his guinea pigs or observing minor breeding changes?
  14. Our dominant genes are expressed during fetal development affecting sex, height, eye and hair color and many metabolic processes. Do all 46 chromosomes come into play postnatally regarding such things as hormone production and all manner of transcription-translation regulatory process? why not? All 46 chromosomes are part of the chromatin. why would an RNA polymerase not wander over to a recessive gene and put it to work? Especially if the dominant gene was damaged or working inefficiently. Perhaps the distinction between dominant and recessive evaporates after fetal development allowing the environment to call all shots regarding which genes are active among all 40,000 genes not just the human haploid 20,000.
  15. Genetic change has been conflated with, confused with evolution throughout the latter half of the 20th century and the 21st. Calling allele frequency change “evolution” is like calling a grain of pollen a pine tree – well…..it sort of is and sort of isn’t with a 99.9999 % chance that the pollen grain is just another allergen – a sneeze at most. Fisher, Haldane and Sewall Wright explored genetic change. that their theories have been framed as evolution was to jump to conclusions. The core notions of the Modern synthesis are about micro-evolution  – no evolution discernable / provable,  just variation, just change. Variation is not evolution. Discerning pathways of phenotypic change is not discerning pathways of evolution. The Modern Evolutionary Synthesis is not ALL wrong, just ALL too narrow.
  16. Might a bacterium or a virus take a few nucleotides / base pairs from one species of mammal and insert this DNA from mammal One into mammal Two which is a different species from mammal One? Scenario:  Buffalo dying of a viral infection – 50% of his 30 trillion cells have this toxic viral DNA mixed with buffalo DNA in a diseased chromatin soup in 15 trillion cells. A mosquito bites this dying buffalo then it bites a man on his balls infecting a few million germ cells / sperm / gametes with both viral DNA and buffalo DNA, any notable consequences?
  17.  Natural selection does not “cause” evolution any more than an academy award “causes” a fine motion picture or a Nobel Prize “causes” brilliant research. Natural Selection is an outcome not a cause.
  18. Genetic drift explains sports dynasties  – see: Roger Penske and four-wheel genetic drift.
  19. Investigate founder effects on JB “The Ugly Gene” in New England Settlers-17th century Puritans.
  20. Evolutionary biologist Ronald Fisher, a Darwinian gradualist – key player in Modern Evolutionary Synthesis misconstrued the rate,time and degree of the evolution of animal complexity. Fisher was fooled by outward appearances as 90% of vital biochemical pathways were in place before the Cambrian Explosion at 550 million years ago. All else has been biochemical window dressing, couture for bacteria bags: mammals, reptiles, amphibians and birds i.e. experiments in fashion, trivial in scope. Compare the number of microorganisms to the number of multicell organisms on Earth today. Fisher actually believed a bear is different than a snake.
  21. What was the last common ancestor of the chloroplast and the mitochondria?
  22. Test for correlation of high fructose corn sweetener to mitochondrial fission at fat cells and at kidney, hepatic and gut tissue.
  23. Curing a person of cancer is like curing the Earth of humans. what would be an effective strategy?
  1. introduce unfriendly microorganism
  2. add excess heat or cold interrupting metabolism
  3. add dust to interfere with breathing
  4. eliminate food supply
  1. How does one target a single species? what is unique about this cancer family of cells? What is unique about this organism? In humans – the neocortex
  2. At cancer cells  interfere with mitochondrial energy production, dissolve cancer cell membrane, dissolve cancer cell nuclear membrane.
  3. Is the cell outer membrane made of identical lipid bilayer as its nuclear membrane?
  4. Age-old problem: how to direct cancer battle to cancer cell mitochondria only?
  5. Do different tissues have unique mitochondrial DNA? Is liver mito DNA different from that in lungs,heart or kidney?
  6. Review DNA/RNA methylations – differences in various tissue cells. How is a hepatocyte mitochondrial methylation different from a lung cancer cell mitochondria methylation?
  7. To do: Examine 1,000 different cancer cell types to determine differences in their mitochondrial DNA/RNA epigenetic modifications.
  8. This must all be old hat: Target DNA-RNA promoters that are unique at cancer mitochondria to interrupt energy/metabolic process thus killing the cell – starve cancer cells of their glucose.
  9. Do brain tumor cells have unique mitochondria from the brain area tissues of origin. Does each brain area generate unique tumors each with its own signature?
  10. What is the cancer equivalent to the effects of disruption of neocortical function, neocortical links with brainstem, striatum etc. intra-cortical links re: sensory perception. Inter-cortical links re: efferent signaling between neocortex and hypothalamus, thalamus, globus pallidus, putamen, pons, medulla, cerebellum, hippocampus? Cancer-human analogy.
  11. Cancer cure? 24/7 low level ultrasound or uv/infrared light ( something besides traditional radiation-chemo) bombardment geared to upsetting cancer cell mitochondria reproduction i,e, cell division / proliferation. to do: determine quantum level electrical processes/pathways at mitochondria. Halt methylase and or polymerase proliferation.
  12. bio-friendly coated Nano pulsing device inserted into tumor-wireless operation with belt battery pack. Call it the BQMD: Blake Quantum Mitochondrial Disruptor.
  13. Cure cancer by disrupting RER (rough endoplasmic reticulum) adhesion at ribosomes during translation to disrupt lipid production and thus disrupting cell membrane formation. Reverse the hydrophilic property at carcinomal lipid membrane. If there is no hydrophila there will be no cell wall – get to the root.
  14. Cure cancer by control of TOR target –  rapamycin regulation of cell growth. TORC2 regulates cell surface area by influencing lipid production and intracellular turgor. Interrupt TORC2 transcription, translation or transport.
  15. Cure cancer by stopping golgi apparatus from packaging proteins for export to adjacent / daughter cancer cells.
  16. Cure cancer by inhibiting normal cell function at any and or all organelles and all biosynthetic, transcription, translation and lipid production one organelle at a time.. disrupt one-disrupt all. determine the most fundamental metabolite and disrupt it with a wavelength of sound or light.

***

January 25, 2015    10:53 am

 

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Selfish Chromosome ?

At early Earth, 3.8 billion years ago, there were trillions of free-floating small strands of DNA comprising only a few dozen base pairs. This DNA evolved over the course of 200 million years from free-floating RNA that had coalesced within the primordial soup 4.0 billion years ago. Is a 48 base pair strand of DNA a living thing? When this DNA is split apart by static electricity it becomes two pieces where before there was one. Lightning strikes and the population doubles as each cleaved part restores itself to wholeness.

The notion of free-floating DNA or RNA molecules coalescing in the primordial soup  four billion years ago or tumbling around in hot vent pools two billion years ago deep within a ten mile thick ice crust for 500 million years until a reason to exist materializes  makes as much sense as a quarterback with his 500 plays wandering around in a Mardi Gras parade. DNA is a part of a system, part of a team. The system begins as a simple colony of actors evolving into a more complex system. The DNA system comprises many different types of molecules and many types of organelles: the cell nucleus, the nuclear membrane, the cell membrane, golgi apparatus, mitochondria, endoplasmic reticulum, ribosomes, the nucleolus, chloroplasts, microtubules, vacuoles, promoters, enhancers, tRNA, RNA polymerase, mRNA, etc. All are part of the DNA system.

The cell itself and all of its components is part of the DNA system: plant or animal. Was there once an array of organettes, precursors of organelles? Did organettes combine forces one by one and two by two,  over hundreds of millions of years of symbiotic mergers? It was not only the symbiotic merger of  mitochondria with the cell  but all organelles/organettes merging via symbiosis in the dense, crowded, high pressure world of snowball Earth’s dark hot pools, warm lakes, cool seas  or surface pools exposed to sunlight 2.3 BYA. The organettes formed colonies in the primordial pockets. Colonial structures held together by porous webs of microtubules followed by total lipid membrane enclosure.

The first life on Earth emerged 3.5 billion years ago ( BYA) seen now as biogenic graphite. The second life on Earth evolved 3.48 BYA and is seen in fossilized microbial mats. All living things have DNA. DNA comprises four small molecules: adenine, thymine, cytosine and guanine. Three of these components of DNA: guanine, thymine and cytosine, have an oxygen molecule:. Oxygen did not occur in the Earth’s atmosphere until 2.8 BYA. Question: How did life, with its core genetic component of DNA evolve for 700 million years without oxygen in the Earth’s atmosphere? Was the oxygen derived from rocks or from water condensing from volcanic gas? Did earliest life evolve on the surface of rocks where it could suck the oxygen needed for nucleotides from within the stone? did early life send microtubules ( straws)  into this rock to suck in oxygen?

The systemness of DNA replication- transcription-translation argues against a bunch of free-floating molecules colliding with one another in the primordial soup to positive evolutionary effect. Systems don’t work when the important parts are not present. Absence of oxygen is a theory crippler.  Perhaps the DNA got its oxygen from the water thus an argument for first life being waterborne and eventually spongy-corally-clammy-fishy. Did all aerobic life emerge from the water not the land? The land had no significant oxygen in the air above, not enough to accelerate evolution, until 1.8 BYA.

During the Huronian global glaciation 2.4 to 2.1 BYA the entire Earth was an iceball with ice five to twenty miles thick all over the Earth’s surface. The Earth’s ice crust was pocked by thousands of volcanic vents creating warm pools-lakes-seas in the darkness deep within the ice sheet. The intensity of molecular activity in these pools, each with its own chemical signature, accelerated collisions of all molecules raising the chances of positive symbiotic effects.

Is the DNA system is the product of bioengineering by an advanced species on a distant planet – a designed system invented  by creatures whose bodies do not use DNA in their life processes? Perhaps The DNA system  didn’t evolve in nature anywhere in the universe or in an adjacent universe accessible via quantum string tunneling. The DNA system emerged from generations of experimentation and calculation – alien thought. Was Earth seeded with its DNA system? Perhaps a few million archaea  released in the primordial soup 3.5 BYA from a spacecraft long dissolved or not. Check those streaks of color in the polished marble next time you’re standing near the restroom wall in a major airport. Due to its systemness,there is no such thing as a selfish chromosome or a selfish DNA molecule. A selfish cell? We know that cells work very well with others. If the DNA is not selfish, the gene is not selfish.

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JB Questions-Observations:

  1. What proteins regulate intracell proliferation of mitochondria? Are these mitochondria-regulating proteins from the cell nucleus or from the mitochondria DNA?
  2. Imagine a wheatstalk as thick and tall as a redwood. One stalk the source of 10,000 loaves of bread.
  3. What part of the human brain carries epigenetically conserved ideas about myth, religion, cosmology, etc.?
  4. Experiment: Analyze past 90 years of Hollywood motion pictures noting the elapsed time between cuts and between scenes – note change in implied audience attention span over the decades. Note the elapsed time of either Joey Bishop or Sammy Davis,Jr standing or sitting doing absolutely nothing in Sinatra’s Rat-Pack movies.
  5. Do Christians harvest ( destroy ) their tall poppies ( prominent people) as some sort of sacrifice to their God? See: Durkheim “Elementary Forms of Religious Life”
  6. Was the 3-in-One oil marketing machine trying to capitalize on Christian dogma to sell lubricant for squeaky doors?
  7. RE: distinctions between the sacred and the profane. If mankind has access to it, has power over it -is comfortable with it or enjoys it  then it is profane – all else is sacred. The Woody Allen Club Membership Test is at the root of all religions.
  8. Profile all people who see themselves as leaders of a cult with at least 50 members – New Age, Self-Improvement, Witchcraft, etc. A breed of self-assessed “higher” consciousness folks – the plant intelligence-shamanic-tantric crew holing up along the Santa Cruz-Monterey coast. Are these cultists on to any incipient religion? Yes,  but which will endure?
  9. Emile Durkheim was splitting hairs in 1912 when describing the difference between magic and religion. the difference is as follows: Since one hundred percent of humans create/crave/lean-in to the notion of the sacred and profane, magic is any and all of those practices not officially sanctioned by the dominant party-approved religious order. Those not in line with the governing religion are witches, magicians, outliers, Others and probably mentally ill and in need of medication or institutionalization ( see: Foucault “Madness and Civilization”. Magic and religion have nothing to do with a practitioner’s tendency to socialize. Durkheim is naive and narrow regarding his distinction between magic and religion.
  10. The sacred is Yin, the profane is Yang, they define one another. Each is necessary in order to define the other, to supply le differAnce. See: Jacques Derrida “Grammatology”.
  11. “Green Beard” effects as epigenetic behavior transmitted via neocortical spiny neurons. Green Beard behavior is that in which people favor their own sort. You gotta green beard like me? Yes – you’re in like Flynn.
  12. What did young Le Corbusier learn from Frank Lloyd Wright’s Wasmuth Portfolio projects by 1914? What seeds were planted  by Wright’s Prairie-Style buildings?
  13. RE: origins of first spoken language: afferent sensory neural network reaches critical mass i.e. overloads from intense stimulation of hand on a burning coal and a word spontaneously pops out of the neocortex-voicebox-mouth such as AWE or OWW !  which transforms into Hot. YAWEH ! into God. BRRR – shivver into hiver ( fr)- winter- cold. Infant’s first sounds: goo goo, dada.
  14. Investigate multi-sense stimuli from sense apparatus to basal ganglia to signals @ neocortex. What is the neural network synaptical critical mass required to stimulate word formation?
  15. Each of the sciences, social sciences, arts, politics and law has created its own dense rhizomic mat comprising myriad symposia, documents and experiments, thousands of theories, some credible dogma and plain BS  to protect students and practitioners from the void. There are over one million scientific research papers published in the past thirty years whose contents have not been verified due to the busyness of all scientists with their own work.
  16. Review the structure of the slime mold vertical pod-net structure as a small bag for proto-organs 600 million years ago, organs jostling for position within this useful prefab structure that eventually evolved a backbone and symmetry-body morphology stored in HOX genes. It grew fins and swam into deep water in search of a meal.
  17. Were there ever  free-floating precursors to the kidney, liver, heart, brain or pancreas and or sex organs that discovered advantages by sharing skills. “I’ll pump your blood if you’ll filter mine.” “If you help digest my meals I’ll increase your oxygen supply.” “I’ll be your operations center if you’ll fight off the big bad guys.”
  18. Why would two nucleotides ever want to link up to form a base pair? Was this a forced marriage? A marriage of convenience? Just because they could? A happy accident? An unhappy accident? Crazy kids? Did they break apart soon after for a million years alone then reunite?
  19. Has there ever been a living cell without a bilayer lipid membrane? with just a hairnet sort of enclosure surrounding its organelles?
  20. A key reason for mitochondrial symbiosis was to provide a source of cell energy when DNA is locked up busy preparing to divide at mitosis-meiosis and not able to engage in protein transcription-translation. All protein synthesis must taper off while cell is dividing and re-starting its scheduled protein production. Mitochondria provide interim energy due to its separate genome not tied up in the cell’s general chromosome duplication.
  21. Is there a unique RNA transcriptase for each different protein produced by a cell or does a single RNA transcriptase molecule start all protein production with intron-exon editing or protein tagging via methylation/ phosphorylation providing the proteinic variation? How unique must a protein be in order to warrant its own unique RNA transcriptase that is present prior to start of transcription?
  22. What cell type has the most mRNA types? JB guess: auditory hair cells.
  23. Do auditory hair cells require many hundreds of alternate splicing pathways diverging from a small number of tRNA and or RNA polymerases directing the synthesis of the range of proteins needed to detect 500 different pitches?
  24. Religion or magic” The cult of genetics central dogma; what’s not to believe? Dig the dogma -it’s life and lab-tested.

January 13, 2016    5:49PM

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Kuchen’s Dam

KUCHEN'sDam

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Beyond the Base Pair

 

DNA comprises four nucleotides: adenine, thymine, cytosine and guanine. these bases pair with one or another into base pairs. There are two options for these four bases as thymine only pairs with adenine and cytosine only pairs with guanine. Each of the nucleotides is represented in writing as A,T,C,or G. A only pairs with T and C only pairs with G. The human genome as it occurs on our 20,000 protein coding genes  comprises only these four bases in an infinitude of possible sequences. the average gene is 1,500 base pairs long. The average chromosome ( they are all a unique length) has 139 million base pairs. Only two percent of the human genome codes for protein. the rest has either a regulatory function or it is dormant. If the average DNA molecule ( one DNA molecule per chromosome) was one sixteenth of an inch wide ( a piece of string) it would be two miles long. Each one of a human’s 10 trillion cells has a full component of 23 pairs of chromosomes, forty six total in each cell. Every gene occurs twice – one from mother one from father. there are 3.2 billion base pairs in the human genome, 6.4 billion bases.

If you have studied biology in the past 45 years you are familiar with the appearance of our 46 chromosomes all coiled up into wormy looking pairs, aligning at the center of a dividing cell and travelling to opposing sides of what has become two different cells. DNA is only bundled up into worm-ish chromosomes when replicating; at all other times this DNA is unspooled into a gooey mass of glop. A  few hundred ( of 20,000 plus) locations where the base pairs have been enzymatically separated to allow genetic information to be transcribed from the DNA in the cell nucleus to a ribosome sitting on the rough endoplasmic reticulum surrounding the nucleus where the proteins specific to that cell’s tissue type and the proteins needed for the cell’s shared metabolic needs are manufactured from amino acids suspended within the cell. Amino acids are building blocks of protein and protein is the building material for muscle, nerves, bone, blood and brains, all sensory organs and all hormones. We are protein. Protein is amino acids, the sequence and shape of amino acids is determined by DNA:  the specification for each plant, animal, bacterium, virus, archaea, fungi and mold.

There is ten years of research into the addition of a third base pair to the organism genome. E.coli bacteria are the medium of choice to date for these experiments. Bacteria multiply at an intensely high rate. E.coli bacteria double their population every 17 minutes by binary fusion in geometric progression. Bacterial growth is exponential: 1,2,4,8,16,etc If a third base pair is accepted into the blueprint of life and it enters via bacteria. this mutant DNA could spread to every living thing on Earth within a few years. Is it prudent to experiment with a fundamental building block of all life in such a cavalier manner – no. Life works fine most of the time – why wreck a good thing, a great thing. Just because life can be fooled to accept this UBP ( unnatural base pair) this third base pair, does not mean that good things will ensue. A third base pair integrated in all of the DNA of the human genome would be to throw ten thousand wrenches into our DNA spokes upsetting all inheritance of internal and external physical characteristics and any metabolic process – the whole works. Old turkish proverb: Any fool can throw a turd into the well  but it takes 20 wise men to get it out.

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Questions and observations:

  1. We live in the age of the network aka the rhizome. the age of the hierarchy is over. Look at the map of the major cities of the USA on the back page of your in-flight magazine. Note the connections between cities indicated by multiple webs of red lines radiating from each city. This is the heuristic of our time. The hierarchical ladder no longer functions for us. Imagine this map in real time and space, as pulsing intracity networks, our population on I-Phones, the traffic patterns, the infrastructure patterns: water, sewer, gas and electric lines, fiber optic cables, telephone lines, social networks: school boards, little league teams etc etc.
  2. American tribal ritual of intercity flight within aluminum tubes at 40,000 feet. Sit back and relax, absorb the insane zeit from security paranoia theater at the airport to kidney and liver-killing soft drinks and alcohol in a jam-packed microorganism airshare,  pandered to with peanuts and the latest Disney movie as the wonders of the universe pass below little noticed.
  3. All life on Earth is a video game played in an alternate universe operating within our quantum emptiness filling each living thing: plant, animal, bacterium. Myriad hands in gloves guiding all to victory.
  4. When eating an egg, a person ingests a lot of DNA, ribosomes, rough endoplasmic reticulum, golgi apparati, RNA of all stripes, mitochondria, lipids etc etc – a smorgasbord !  Protein of many varieties in this broad mix of nutrients.
  5. Compare and contrast: “The Good woman of Szechuan” by Bertolt Brecht and “Glengarry Glen Ross” by David Mamet.
  6. JB essay title: The Mystification of Repressed Myth (bubbling up from archaic depths ( 1940s)  into consciousness via Turner Classic films.
  7. JB essay title: “Corrosive Reification-Sinatra’s Rat Pack” or “Why does Joey Bishop Just Stand There?”
  8. Is there a gene that accelerates epigenetics? that accelerates the acquisition of acquired rather than evolved characteristics?
  9. Did gene transfer occur between horses and humans allowing the proliferation of epigenetic pathways to evolution?
  10. Did horse teeth, enabling grass chewing, evolve via epigenetics?
  11. Did the human outsize neocortex evolve via epigenetics?
  12. JB neolog: Pooze or P.ooze or Primordial ooze: ancient sea/swamp/tideflats/ponds 4.0 to 4.5 billion years ago where the ground rules for organism metabolic process were established. See: Krebs cycle etc.
  13. A wild-ass guess: There were 2 million donkeys on the North American continent 2 million years ago.
  14. Humans may or may not have killed off the horse in North America – humans scared the entire horse population away across the Siberian land bridge. The horse did not go extinct in North America, it left the premises. Horses are smart.

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12/31/15  7:20PM

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