Ingest – Evolve

 

Nature stopped taking big chances half a billion years ago. All change in plants and animals since then has been cosmetic – a lion here, a zebra there, here a monkey, there a chimp – let’s add some brains and see what shakes out.

Nature abhors a gradient. This is the deepest fact of life on Earth. There is a gradient between the Pre-Big Bang omniverse and the void. That gradient generated the Big Bang.  There is a gradient between the heat of the sun and the void of outer space generating life on Earth. A gradient between life itself and all of outer space that gives rise to all human culture aka the technium. The technium-void duality generates autos, washing machines, I-phones and digital communication and so on down the hierarchy of stuff ad infinitum. Life on Earth emerged and has developed to reduce a gradient.

Prokaryote: a single-cell organism without a nucleus. Bacteria and archaea are prokaryotes. There are more species of bacteria on Earth than any other life form. Bacteria comprise a large proportion of the Earth’s biomass. Archaea are simpler than bacteria and live in extreme environments and were Earth’s first living things 4 BYA (Billion Years Ago)

Eukaryote: An organism whose cells contain a nucleus. Eukaryotes may be single-cell ( but much more complex than bacteria) or multicellular as in all higher forms of life. Plants and animals are eukaryotes. All cells in a human have nuclei. Mnemonic: Humans like YOU – EU  are EUkaryotes. All plants are eukaryotes.

“There never was a simple eukaryote cell – all complex life evolved from symbiosis of a primitive archaea and a bacterium. The cell nucleus and all other organelles evolved after this merger.”  –  Professor Bill Martin

All forms of animal and plant multicell life evolved from the merger of an archaea and an energetic bacterium – a single event in the history of life. Neither of these independent, free-floating prokaryotes had a nucleus or any complex organelles seen in cells today or 2 billion years ago at the time of this fateful merger. The energy gained by the acquisition of the energetic bacterium fueled the evolution of cell complexity, multicell life and the speedy evolution of diverse forms enabled by sexual reproduction i.e. the mixing and matching of two separate genomes for an improved model.

If biologists were carved into Mount Rushmore the four heads would be Charles Darwin, Gregor Mendel, James Watson and Lynn Margulis. Lynn Margulis !  Who the hell is she !   Lynn Margulis, when a grad student in 1967 , wrote a scientific paper called “On the Origin of Mitosing Cells” that proposed that chloroplasts and mitochondria,  the vital energy-producing organelles in every eukaryotic cell, were ancient free-swimming microbes that merged into a neighbor cell to form a potent symbiotic duo that has evolved from a single-cell organism into all subsequent multicellular plants and animals on Earth for past two billion years. Margulis was ignored, marginalized or disparaged for many years after the publication of her paper but she persevered with her revolutionary theory and with the techniques of genetics developed during the late 1970s,  her theory gained traction.  Biologists now believe that this symbiosis was the single most important event in the history of life on Earth. It made all multicell life possible and gave rise to sexual reproduction and wide opportunities for cell complexity, purpose and genetic variation-evolution. Margulis’ reputation evolved from that of a shunned outlier to widely hailed genius in ten years.

Why was this Margulis Merger of simple but energetic bacterial cell and plain simple archaea so successful two billion years ago? What was happening inside cells that was not happening during life’s first 2.5 billion years? This new partnership greatly accelerated the role of life as a gradient reducer. Life was now going to help the cosmos reduce the difference between the chaos of the sun and the orderly cold, dark stillness of empty space at a much greater rate. Life exists to restore the order of emptiness. The bacterial partner of this historic merger evolved into mitochondria ( chloroplasts in plants – the things that make plants green). Mitochondria are tiny boiler rooms with thousands of molecular engines ( ATP synthase proteins), nano proton pumps, whirring and chumbling as they reduce atomic gradients across mitochondrial / chloroplast inner membranes. Proton pumping molecules  generate and store energy used throughout the cell for protein production, cell replication, neuron signaling and all other cell functions day and night for the lifetime of the plant or animal. The Margulis Merger between bacteria and archaea ( see: Martin and Muller theory for details) speeded up life by a power of ten. Nature loves this successful, long-lived  marriage of microbes. The merger greatly accelerates the reduction of the solar-void gradient. Big life speeds up the race to nothingness – nature’s comfort zone.

How did this marriage of two small, inefficient prokaryotic organisms occur? 2.5 BYA the Earth was all ocean teeming with trillions and trillions of archaea, bacteria and viruses-all very simple life forms with no cellular complexity.  Due to the effects of orbital precession ( Earth’s wobbly diversion from a perfectly elliptical orbit in a perfect plane around the sun) and axial precession ( Earth’s wobble about its axis in 40,000 year cycles that cools and warms the planet) Earth entered an ice age during which the oceans began to freeze far beyond the polar region to the equator. This freezing created intense overcrowding among microbes. The albedo effect of a snowy Earth further accelerated this ice formation and compressed all microbes into a vast soupy freezing mass. Imagine a vat of rice five miles deep with each grain a living thing. The pressure at the lower reaches is immense, bodies merge, cell barriers are violated. 95% die from the shock of intermixing and the harsh environment. One pair of merged microbes survives with the energy required to fight for a place near the warm water. It warms itself and reproduces around a lens of melted water around its thermal vent. The same vent that created this life two billion years previously. Life had come full circle in the first 2.5 billion years – back to the vent but still as only a single cell with a powerhouse passenger. So we have our merged pair of microbes multiplying in this deep, dark but warm pool of water. A crack forms in the five mile thick ice crust reaching the surface and sunlight. Descendants of the original merged pair move with their new energy up to the light where solar radiation further speeds mutation-evolution. The ice melts over the next 100 million years, oceans gradually reappear and this new form of life, with its built-in powerhouse, thrives and dominates every niche. Land emerges from the sea, oxygenated atmosphere forms. Environments differentiate across the planet and plants and animals differentiate filling every niche. Unicellular life explodes into myriad multicell varieties. The race is on.

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JB Questions and Observations:

  1. Reading a book is a gradient reducer. There is a magnetic gradient between a great unread book and a reader that begs to be eliminated in the service of the universal law of entropy. Reading a book causes life to grow just as life grows from the solar-cosmic gradient reduction engine.
  2. There is a gradient between an author and a story to be told whether fiction, non-fiction, memoir or cookbook. The stuff of story is a set of events that transpired to reduce social gradients public and private. The protagonist swears “The devil made me do it – the gradient had to be reduced !”
  3. Our social hierarchy is a finely tuned gradient comprising signals such as net worth, education, manners, age, good cheer and health. Our conspicuous commodities are shorthand messages;  symbolic-totemic-talismanic abstractions for wising up others about our social standing in the technium. Dress for success. Where highlife meets lowlife at any of the above, the stuff of story emerges: wealthy woman meets impoverished poet = fireworks. Healthy teen meets autistic new kid on block = drama. Educated flower vendor meets dimwitted aristocrat- hijinx ensue. Combine three gradient disjunctions in each character for drama. Mix n’ match these elements of the great convection engine that is human society. Reverse gradient expectations – rich girl is kinesthetically challenged ( crippled from polio). Poor boy from slums is a mathematical genius, etc. What is a fish out of water ( one of seven classic story tropes) but a gradient waiting to be reduced?
  4. If the nuclear proteins NOTCH and P53 can make edits to DNA then a G-rev ( positive genetic mutation) at the P53 and or NOTCH gene can affect evolution as much as a great many base pair revisions.
  5. Are skin pigmentation and muscle composition controlled by mitochondrial proteins? People of different races burn muscle energy at different rates. Mitochondria are the source of all cell energy.
  6. Is there a link between toxic effects of high fructose corn sweetener and free radical leakage at mitochondria?
  7. Is the microscopic hydra in the same clade as squid?
  8. Was Noah’s flood caused by a glacial dam burst similar to the Missoula Flood that washed over Central Washington, Western Oregon and central Montana and covered this vast area in less than a day.
  9. Would the pressure of a five mile thick ice sheet have caused the lower level to remain unfrozen – a vast, dark, thin and deep ocean all around the globe? Would this glacial-melt ball bearing lubricant layer have made the entire Earth’s ice shell subject to tidal pull of the moon? Would the “low tide” inner ice ball surface have crushed one trillion microbes into one another twice each day forcing the issue of symbiosis?
  10. Could the momentum from a colossal, immediate release of water from a glacial dam burst cause either axial or orbital precession or both?
  11. Would this water interface between the iceball shell and the rocky Earth act as a ball bearing inducing rotational differential between earth and ice shell? Would rotation differential generate heat warming the deep thin water layer making it more suitable for evolution? Expanding warm water beyond thermal vents to the entire layer of melted ice?
  12. Are there correlations between Glacier lake- Earth orbital-axial irregularities and evolutionary events in the history of life?
  13. Has epigenetic inheritance had an effect on human tool use and the development of human culture? Is there hardwired  genetic culture memory i.e. human culture transmitted by cellular stuff in addition to books, language etc.?
  14. There are three, four, five or six kingdoms of life on Earth depending on which scientist you ask. I like the six kingdoms model: 1.Plants-eukaryotes 2. Animals-eukaryotes, 3. Protists-single cell eukaryotes 4.fungi-eukaryotes  5. Archaea-prokaryotes 6. Bacteria-prokaryotes
  15. The are three domains: 1. Archaea, 2. Bacteria 3. Eukaryotes
  16. Slime mold has tentacles up to several yards long. Neurons in chordates have axons up to three feet long. Is the human neocortex a slime mold symbiont? Our brainstem covered with 85 billion slime connections evolved from a symbiotic parasite – the source of our “higher” intelligence. Perhaps higher is a misnomer as this explosion of network capacity may turn out to be disadvantageous for planet health.
  17. Is there more wood in the crossties of railroads or in all wood frame houses?
  18. Kevin Kelly, former executive editor of “Wired” magazine, proposes a neologism to encompass all of human culture, a single word: The technium – useful !
  19. What were the health effects of lead water pipes in Ancient Rome. Did decaying mental capacity caused by lead poisoning cause the demise of the Roman Empire?  

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4/25/16    4:15PM

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Neuron Sparks

 

“Equilibrium is death” – Dr. Nick Lane biochemist

The term Darwinian implies evolutionary change that is small and discrete. It may be small but it is interconnected in countless ways-not at all discrete.

We tend to think of whole animals evolving. Humans are a whole animal. We conceive of ourselves as a single unit but molecules, enzymes, lipids, nucleotides, genes, organ systems and relationships between organs evolve, quantum relationships evolve. Many levels of hierarchy of living systems co-evolve in a single organism. G-revs ( positive mutations)  must coordinate with all others. A G-rev increasing the diameter of the ureter can upregulate the entire body in a single generation by positively affecting 10 trillion other cells. All systems in an organism must evolve in concert. All cells must communicate with one another. How? Sensory systems, messaging systems: quantum, atomic, chemical, mechanical communication throughout the body 24/7/365/life. The term “natural selection” doesn’t begin to suggest the scope of this inter-intra-organ communication. Competition in the real world of pine trees and bears is a trivial subset of behavior at the organism level ( the whole feeding, fighting f-ing animal). Does an RNA molecule compete with another RNA molecule or an enzyme? – no – but it communicates in many ways.

Ninety nine and nine tenths percent of all evolution occurs deep within the bodies of animals as G-revved somatic cells divide and multiply mixing and matching genes for improved function ( evolving)  through a single lifespan in many cell divisions from tens to hundreds to many thousands. A human has 10 trillion ( with a T !)  somatic cells distributed among twelve organ systems, featuring five vital organs: brain, heart, liver, kidneys, lungs. These organs speak to one another genetically during a single lifespan.

We traditionally hear about evolution in the form of animals fighting for sex and survival with the genes of winners proceeding to next round as offspring benefitting from G-rev. This is Modern Synthesis dogma ( Darwin meets Mendel) the core of contemporary biology – the Kool Aid of our time – Don’t drink it.  For every battle between two lions, tigers, bullfrogs, snapping turtles or humans there are 50 trillion instances of cooperation and communication between cells in the service of DNA modification and evolution. Darwin’s “red in tooth and claw” trope is nano-trivial. Selection happens between somatic cells – other arenas of the hierarchy, from tribal populations to quarks are trivial.  A new generation of major organ cells carries a net positive array of mutation or net negative array. The bad die young.

G-rev occurs 24/7/365 in every cell in our bodies. A mutation might serve a heart cell but throw the liver out of whack. Organs communicate genetically via chemical and electrical signaling coordinating G-rev among themselves. All for one – one for all. The positive accepted revisions are then registered in the germline DNA. G-rev is transmitted to the following generation. You could accrue one gazillion G-revs throughout eleven organ systems before you are twenty years old but if this G-rev bounty doesn’t appear in the germline when you mate, it’s sayonara to all of that potential improvement of the species. Nature is wasteful but it’s not stupid.

How do all cells communicate with one another, germline included,  re: the usefulness of the latest mutation.How do the cells of our body communicate with one another? What is the pathway-vehicle- mechanism- medium? How are messages sent and received re: fitness of a mutation? Each of our twelve organ systems is crawling with neurons. Neurons are found throughout the vertebrate body not just in the brain. Most of us have by now heard of our gut and heart brains. We also have a pancreas brain and a lymphatic brain and a liver brain and a kidney brain.  This population of neurons beyond the noggin sends gene-altering signals, mobile introns customized via neuron sparks,  through a  rhizomic neural network. Individual cells work together swapping information through the nervous system evolving in concert, giving the improved animal an advantage in head- butting. The primary arena of evolution is not jungle or ocean but infinite realms within each organism.

JB Teapot ( see: Russell’s Teapot) There is a clearinghouse in the brainstem collecting, sorting and distributing genetic information from neural systems of specific organs. Afferent ( incoming)  information is compiled, sorted, compared, coordinated, summarized and coded then sent as a package to the germline for transmission to next generation of the whole organism.

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JB Questions-Observations:

  1. Is differential gene splicing involved in synthesizing hundreds of pitch and hue proteins of the cochlea and retina? Are the hundreds of different perception cells coded via post-translational modification ( phosphorylation, methylation, ubiquitination, etc)? See Notch proteins for most likely path to cell specificity.
  2. How much birdsong occurs beyond the upper range of human hearing?
  3. Each of our ten trillion cells has one million tiny energy factories ( mitochondria). Keep your mitochondria happy with a walk around the house a few times a day for better health – wake them all up with exercise. If they are awake and fulfilling their destiny they will make you happy. If they remain static they will kill you in 1,000 ways.
  4. Investigate the effect of high fructose corn sweetener on afferent neural function at hepatic cells ( liver). Does HFCS wreck signal processing via osmotic or osmolality  CA+2  or K dysregulation
  5. Investigate induced remote organ G-rev, coordinated mutation, coordinated post translational modification to be encoded later in genome as base pair mod or histone acetylation, phosphorylation, methylation re:
  1. leukocyte influx at liver
  2. Channel-inducing factor at gut
  3. Vascular permeability at lung and or brain
  4. Neutrophil trafficking at heart
  5. Granulocyte colony-stimulating factor at brain
  6. other
  1. JBT – The Blake Lens ( incorporating Dr. Nick Lane’s  theory of Proton transfer) A circulating pool of melted ice water four miles below the ice sheet of snowball earth during the Huronian glaciation 2.4 billion years ago as possible location of emergence of life. The ice in small, deep zones in the ice block is melted by an alkaline thermal vent that pushes mineral-rich water from heated rocks far below through spongiform mineral towers forming proton gradients across membranes where organic chemicals lodge in small holes between flowing mineral rich water of differing PH, a chemiosmotic reaction. There is great pressure from weight of ice sheet in the presence of hot and cold water creating  convection in the water as it travels from the zone of the heated vent tower into the chilled outer zones of the dark pool. There is a crack in the ice to the surface of the ice sheet four miles above where a pool of melted water is exposed to solar radiation. The Blake Lens provides an environment ideal for an orgy of endosymbiotic lateral gene transfer- experimentation.

JB Experiment: Locate existing thermal vent, flush and scour its internal compartments ( micropores) of all organic residue – create a clean breeding ground for new life – see if any new life emerges.

  1. Is there neural crosstalk between lungs and pancreas? Liver and lung? Is there Notch protein crosstalk in these organ systems?
  2. Ivy league universities are among the largest hedge funds in the world according to Ron Unz. JB idea: open these Ivy Hedges up to general population of investors multiplying their cash which is redistributed to students for free education at Ivys and elsewhere.
  3. Do inorganic molecules undergo any sort of selection – natural or otherwise?
  4. Organic matter itself is a great enzyme speeding up gradient reduction between the sun and outer space. The sun and the great cosmic void create a thermodynamic anomaly violating entropy that must be erased.
  5. Was the Big Bang a gradient reduction event erasing disequilibrium between adjacent universes?
  6. Investigate chains, cascades, hierarchies and taxonomies of disequilibrium from the big bang-adjacent universe to the sun-cosmos and all others down to  membrane osmolarity and beyond, down into microcosmos.
  7. Would breathing antibacterial bathroom disinfectant ( dimethylbenzyl ammonium chloride)  kill pneumonia in an infected person? If so, it would be less trouble than a doctor. Cure pneumonia in five seconds – don’t try this at home yet.
  8. JB neolog: Capacitor Effect: great reactivity built up behind a kinetic barrier that is released in an instant.
  9. Would UV radiation be more likely to stimulate the origins of life in an atmosphere without oxygen? Is there something prohibitive about oxygen that gets in the way of early life? Life emerging from non-life?
  10. Meteorite carrying cosmic amino acids crashes through the ice during Huronian glaciation 2.4 BYA (Billion Years Ago) and drops amino acid galactic passengers into a Blake Lens filled with mineral nutrients and proton gradient infused membranes – voila !  LIFE !
  11. A hurricane ( or any weather system) is a dissipative structure dissipating energy gradients.
  12. Is a city a living thing? It consumes stuff: energy, people etc. it grows and sends out new life as suburbs ( mini cities-little copies of itself), it excretes waste, cities die.
  13. If there is a manifestation in the physical world of string theory – strings that interconnect clusters of adjacent universes, why not such a network of strings in the microcosmos at human body or any animal or plant body? Strings interconnecting the cells of all organs with a rhizomic network sending G-rev signals to the germline?
  14. Would the pressure of ice five miles deep at Sturtian Glaciation (850-650 MYA) have crushed all hydrothermal vents into granules?
  15. Investigate migratory, Notch-infused dendritic cells for a role as G-rev messengers at and between all organs, especially from the brain to the germline.
  16. If a retrotransposon (jumping gene) can copy itself across an entire genome then why not from somatic cells to germline?
  17. A single cell consumes 10 million molecules of ATP ( from mitochondria) every second. Keep your mitochondria happy and you will be happy.
  18. What is the effect of ethyl alcohol ( wine, beer,whiskey, vodka etc) on epithelial lining of gastrointestinal tract? Is the pathogen barrier interrupted? Are lymphoid, myeloid, stromal players in this protection negatively affected? Does alcohol make one’s gut open to invasion by pathogens? Does alcohol inhibit barrier maintenance? Effects of ethyl alcohol on mitochondrial function?
  19. Investigate corelation: trapped oxygen differential at ice block between Huronian, Sturtian and Karoo glaciations and evolution. Organics processes at Blake Lenses in each of the three glaciations re: oxygen availability.
  20. Can an RNA molecule of any sort cause a neuron to fire its electrical charge or its chemical charge? Can it prevent such firing?
  21. Investigate: eukaryotic cell nucleus as a free-floating organism like precambrian mitochondria.

April 14, 2016    12:45 AM

 

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Voyage to the Germ Line

 

The current evolutionary paradigm comprises two theoretical arenas:  “The Central Dogma” and “The Modern Synthesis”. The Central Dogma is that DNA codes for RNA and RNA codes for proteins in that order, in that direction. It has since been modified to take into account proteins that modify DNA, that reverse the sequence. The Modern Synthesis refers to the conflation of Darwin’s natural selection acting upon random mutations with the ideas of Mendel regarding the realm of genetics. A  key feature of Darwinism that remains fundamental to The Modern Synthesis is that genetic change via mutation is random, always random, forever random,  NOT generated by the needs of an organism as it lives its life. A key assertion of The Modern synthesis is that genetic information is passed from one generation to the next by DNA in the germ line not by somatic cells. Germ line cells are sperm and eggs, somatic cells are all others, including heart, lung, kidney, liver, epithelium, brain etc. If a cell is not a sperm or egg it is a somatic cell. If a mutation is going to cause a change in the DNA of a mammal,  either positive or negative it will happen in the DNA of an egg or sperm – nowhere else. DNA can mutate to high heaven in 10 trillion somatic cells according to The Modern Synthesis and have no effect on future generations.

Given Modern Synthesis dogma, only one-ten millionth of a man’s cells are available to undergo mutation related to possible evolution.  For women, the ratio of somatic cells to germ cells ( eggs) is 1,000 times smaller. A woman produces 400 eggs per lifetime, a man produces 500 billion sperm. A woman’s eggs are exposed to the possibility of mutation for an entire lifetime. A man’s sperm turn over completely every 30 days i.e. 30 days from genesis in the testes to exit of the body.

I am not a creationist but these two currently operational theories demand the suspension of all reason, logic, common sense and intuition. We are supposed to believe that the future of all mammals depends on cosmic rays caroming through millions of cells from the top of the head to the gonads to strike a DNA molecule located in the well protected testicles or ovaries causing a mutation, with only one in ten thousand of these mutations being advantageous at a single genetic trait somewhere within 20,000 human genes. Believers in this catechism will remind us that mutations can also be caused by the stress and strain of cell division as chromatin wrangles itself up into chromatids at every cell division. We are also told that all cells possess chemical machinery that edits mutations out of DNA. The tales of the Holy Bible are more believable. There must be other mechanisms at work than those proposed in this dual Kool Aid combo. The exclusivity of The Central Dogma and The Grand Synthesis is the stuff of myth. These two time-worn theories comprise a paradigm that has generated much science over the past 70 years. The processes these two theories describe are too limited in scope, too slow and neither takes into account coordination between interconnected mechanical, electrical, chemical and quantum systems of organs and processes throughout the body. It is time for re-vision. Why would nature limit evolution to such an infinitesimal portion of the matter at hand?

JB Theory:

  1. All ten trillion cells of the human ( mammal, vertebrate) body ( adjust total per species) participate directly in evolution via the transmission of genetic information between themselves ( somatic cells)  and between all other somatic cells and the germline in a network. Animal evolution is not limited to random mutation in eggs and sperm DNA.
  2. Rename mutation. The word mutation implies a singular incident and an odd, irregular unfortunate occurrence. The word mutation has overtones of wrongness. Mutants are the stuff of sideshows.  Let’s rename mutation as G-rev (Genetic revision) G-rev might involve DNA or histones or RNA – whatever tags along for the ride that creates a zygote.
  3. Reconsider the hardcore dogmatic element of randomness – little heritable DNA change is random.
  4. RE: random mutation – mutation is replaced with G-Rev ( Gene revision) and random is replaced with directed. Random mutation becomes directed G-rev.
  5. All cells send messages to the germline to be passed to the next generation. Every organ in the body not only communicates with each other’s form and process but all cells of every organ participate directly in productive evolutionary revision i.e. germ cell nuclear material modification.
  6. How does it work? Somatic cells send genetic info in the form of cRNA ( Courier RNA: JB neolog)  to the germ line via surrounding tissue fluid collected in capillaries of the lymph system that runs from the brain dura mater lymphatics to the toes and all around each organ on toward the para aortic lymph nodes serving the gonads.  RNA is then sorted and distributed to growing germ cell matrix for insertion into germ stem cell nuclear material or maturing (mature) eggs and sperm: DNA, histones and RNA. This RNA is tagged at each source organ specifying its destination at the appropriate germ cell DNA or other transmissible nuclear material.
  7. Sperm and eggs and their progenitors are continually processing new genetic information from all over the body.
  8. Over the course of twenty years a person’s skin cells have gone through 200 generations, each involving mitosis, crossing over etc – opportunity for evolution via G-rev. If an animal is able to register these beneficial changes into its genome for 200 generations in 20 years, it has advantages. It is not believable that nature would overlook such opportunity.
  9. Revisions to genetic material resulting in phenotypic expression during the lifetime of a single organism is called epigenetic change. To date this change has been considered un-inheritable for the most part because it is a normal function of somatic cell expression in all non-reproductive organs.
  10. Epigenetic information is not wasted. It is tested within a cell type for a few generations of that cell line and then forwarded to the germ cells. Neurons and all cells of the central nervous system are a part of this forwarding process for new genetic information. Neurons store epigenetic change ( memory) and forward it via the dura mater lymphatic-glymphatic system. Epigenetic change is stored and intermittently transferred to germline DNA via RNA in a reverse of Crick’s central dogma assertion of exclusivity of direction. This reverse directional effect of RNA on DNA has been seen for past 20 years in prion activity and reverse transcriptase studies.
  11. Epigenetic information becomes genetic in an avalanche of edits, updates, revision, change aka G-rev or as tradition has it – “mutation”
  12. G-rev is not typically a random occurrence from a UV or gamma ray strike upon a hydrogen or carbon molecule of a nucleotide, nor is it a collection of broken and re-assembled DNA strands. G-rev at the germline ( sperm / eggs) is constant, voluminous and locked into the genome for transmission into following generations.
  13. There are 220 types of somatic cells in the human body – they are not sterile as The Modern Synthesis asserts.
  14. G-revs are so numerous they appear to be adaptively directed from the somatic cells.
  15. Darwin proposed that evolution took place at the level of the organism in its real world environment the result of generations of struggle to survive and reproduce. Contemporary theorists have suggested the gene itself is the operant realm of evolution ( Richard Dawkins) and others ( Stephen Jay Gould) assert that it is the the species upon which natural selection/genetic drift/genetic flow act
  16. This is how it works: Step One: nuclear material at somatic cells is epigenetically modified as histones undergo post translational modifications ( methylation, acetylation, citrullination, ubiquitination, SUMOylation, ADP ribosylation, phosphorylation) The cell,  in rapid succession says “try this, no this, now this, OK this one’s a keeper”  The cell uses this change for a few hundred or a few thousand cell replications of epigenetic inheritance within the tissues of an organ to test it before sending info via RNA through the lymph system to gonads where oogenesis(egg making and spermatogenesis (sperm making) are underway prior to for further editing and insertion as new G-rev base pair sequence at DNA in Sperm or eggs. Descent with modification at 10 trillion somatic cells followed by descent across organism for trials of offspring against all comers for food, sex, survival.
  17. There is no such thing as non-coding DNA. all DNA at chromosomes participates in sorting, editing and storing somatic cell information prior to conversion into a protein signaling gene.

Our society has a germline seen as movies, novels, art museums,  television, newspapers, magazines, scientific journals, professional sports teams and textbooks. There is intense competition to participate in these avenues of influence. We struggle and conspire to contribute as if we would evaporate unseen into the cosmic ether if our paintings didn’t find a New York gallery or if our screenplay is not turned into a feature film or our scientific paper is rejected by the prestigious journal or if we don’t make the starting line-up on the soccer team. The cultural germline has intensely policed channels. We are trained to believe that getting into this germline matters more than it does. Each life matters as much as the next and all lives send an enormous amount of information into following generations in countless ways – no major label record deal required.

Every person (cell) in the body ( society) signifies and each sends vital information to the next generation by individual, thought, behavior, action, and  mood throughout life. It is the way of the world that each of the carbon units ( us)  plays a role in determining what gets transmitted, what lives and what dies.  Private thought and action is sorted and finds its way to local, state and national influencers,  germline politicians, cultural gatekeepers at school board meetings, elections,  publishing houses and art museums. We vote with our bodies as we drink the fresh water piped in from the water treatment plant, use the sewer system and shop at the supermarket. We vote with our bodies and our pocketbooks as we drive process and product to prominence or decay. We have a choice to litter or not, to smile at the cashier or not. Individual action born of individual thought and feeling  gets collected just as information at ten trillion cells gets collected.

*

JB Questions-Observations:

  1. Perhaps all somatic genetic information is routed via lymph system to the pons first  where it is sorted prior to transport to the germline
  2. There are 323 million people living in the USA. where is the germline? How might one get his / her ideas into it for guaranteed transfer of one’s unique contribution into the next generation. What is the American counterpart to the lymph system G-rev pipeline. A movie screen is like a giant penis shooting spermey ideas out into the audience. A college professor is an erection of sorts firing his material into an audience that might contain a receptive mind or two.
  3. If a railroad track is a metaphor for a society’s path into the future. Would the crossties be individual people? Would the intense regimentation of RR crossties reflect the sameness of language or an array of ethical beliefs, shared religion, marriage rites etc. Would the unique patterns of wear and tear on each crosstie reflect the scope of our individuality?
  4. Bertolt Brecht was the Mother Teresa for the Stalinist incarceration of millions of Soviet citizens. Brecht gave Stalin a free pass from day one until Stalin’s death in 1953. To Brecht, Stalin was a great unifier who defeated the Germans. Brecht chose not to see the millions of Soviet citizens who were interned in the Gulag archipelago.
  5. Brecht was the king of agitprop theater ( AGITationPROPaganda). I wonder if he was on Stalin’s payroll throughout his theatrical career? Brecht was the Picasso of 20th century theater with a great influence on Americans Tennessee Williams, Clifford Odets, Arthur Miller.
  6. Perhaps there has been little need for any organism to ever evolve or evolve from scratch when it can simply incorporate systems from other animals and plants each with its own special gifts. Much biosynthesis ( per Lynn Margulis) Very little new stuff in plants and animals as they evolve.
  7. What was the first organism to see, hear, breathe oxygen, touch, smell, use blood to move chemicals through its body?
  8. What happens at olfaction? How does a smelly molecule affect neurons to sense a smell?
  9. What were the proto-organs for each modern organ?  How were genomes modified to deliver functional units to offspring?
  10. Maybe instead of lymph, the network that transports genetic info from somatic cells to germline is entirely invisible and operating in a quantum network.
  11. Random mutation playing out via natural selection and genetic drift is crude, too undirected even with hundreds of millions of whole life generations across eons. The picture must be bigger.

***

4/2/16    11:02am

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Canals On Mars

“History does not repeat itself – it is historians who repeat one another.” – anon

In 1907 the elder, esteemed American astronomer Percival Lowell claimed to have discovered canals on Mars. He proposed that these “canals” were a last gasp effort of a dying civilization to reroute water from Martian ice caps onto a drying, desolate landscape. Lowell made detailed drawings of these patterns he called “canals” and as a result of his scientific reputation and social status, his exciting idea spread quickly. The wide publication of Lowell’s carefully observed drawings and theory the origin of Martian canals stimulated the imagination of millions of newspaper readers on both sides of the Atlantic including many science fiction writers. The existence of Lowell’s “canals” could not be corroborated by other astronomers and his theory was soon discredited.  Lowell was actually seeing the shadows of blood vessels cast on the retina of his own eyes from his small telescope eyepiece.

This story is ripe for wisdom-mining. There are no canals on Mars; there ARE canals on/in our eyes. Others find it annoying when we make Lowell’s mistake of thinking our canals ( the ones we see on Mars or anywhere on Earth, in our souls, out among the stars) are everyone’s canals if only other people would bother to look as closely as we have looked. When discussing canals ( ideas, beliefs) approach slowly, begin with a hint, you may find a like mind and most likely you will not, if not, let it go. Your canals are yours. Everyone has his/her collection, their canal-baggage aka their mythome, belief system, prejudices, habits, enthusiasms, trails of success / failure, often anxious to share.

Many successful writers latch onto an underclass that they proceed to exploit in their art. Bertolt Brecht exploited the proletariat workers of the world like the good Communist he was. John Steinbeck exploited the unfortunate Okie immigrants seeking work in California. Thomas Mcguane exploits the small town hapless businessman, doctor or rancher of disintegrating prospects. The effective memoirist exploits their own family.

Brecht patronized his oppressed, exploited workers from the vantage point of a comfortable, well-educated member of the bourgeoisie he and his fellow avant-gardists scorned. Brecht exploited the working class as much as any industrialist. The abused worker was his lab rat for his own aggrandizing  theatrical experiments. The workers of the world were Brecht’s “canals on Mars” the burst blood vessels through which a writer sees his subjects. The most successful author is always slumming. Never write of or above your psychic or social station i.e. don’t write about people happier or wealthier than yourself. When a writer of the upper class turns to write about his/her poor little rich people – look out! Literature is in the works – see: Tolstoy. This is AOK,  not criticizing, just noting.

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JB Questions-Observations:

  1. Eight-oar rowing, the most communist in spirit of any sport given its requirement of total subsumption of the individual for the good of the whole enterprise yet competitive rowing has been nurtured in the heart of the Capitalist upper class by the WASPiest of young men and women, destined to the highest levels of Capitalist leadership.
  2. Bertolt Brecht wrote one great play ( adapted) “Threepenny Opera” and one great song lyric “Mack the Knife” the rest is agitprop.
  3. Socialism is sharing of wealth created by all members of society. Capitalism is the hogging of as much wealth as one can get away with and if laws interfere, change them – see: Bill Clinton and friends-Glass Stegall. Feel the Bern !
  4. Brecht’s “Epic Theatre” is Agitprop at its best but agitprop nonetheless. Agitprop = AGITationPROPaganda, a didactic theatrical form meant to instruct audience ( usually poorly educated)  on the value of Communism.

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March 19, 2016    2:37PM

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Rhizomes-Dendrites

 

JB reading: “The Empire of Cotton-Sven Beckert, “The Georgetown Set” Gregg Herken, Bertolt Brecht-His Life, Art and Times”-Frederic Ewen

“Power develops at the intersection of network paths not at the endpoints”

– Sven Beckert

Rhizome: An elongate, horizontal, subterranean plant stem possessing nodes.

Rhizome (Gilles Deleuze def. + -): “The rhizome presents history and culture as a map, a wide array of attractions with no specific origin, no beginning-no end-always in the middle between things, ceaselessly establishing connections between semiotic chains, organizations and power in art, science, politics and social struggle.” Note: Every walk of life is a rhizomic realm, threads of significance, web of meaning. Webs among the cells of the brain tracking webs perceived in the world of all else.  All higher education is about introducing one to the working ( fashionable)  rhizomes of a chosen field – the Kool Aid-catechism-central dogma. Walk the dogma or change majors.  Look for new connections in rhizomes that overlay one another i.e. vertical nodulation: air travel with textile trade networks and internet links. The little-noted but all-pervasive vertical threads – three dimensional fabric – a cube of cloth ( ideas, tropes, patterns, networks) length, width and height – see: 3-D chess game.  Trade routes-nodes, vacation routes-nodes, mosquito vectors.

Dendrite: Threadlike extension of a neuron branching into treelike structure. The dendrites comprise the receptive surfaces of the neuron conducting impulses toward the neuron body and out through the axon. One neuron ( of ten billion in the human brain) has up to 100,000 dendritic spines.

Rhize (JB neolog): A single filament in a Deleuzian rhizomic socio-politico-historic network – Examples

  1. The path of an airliner from Los Angeles to Nashville is one rhize.
  2. A cool shoes meme travels its Gladwellian path from Harlem to the rest of world
  3. The concept of Containment ( of the Soviet Union) from the mind of U.S. foreign policy guru George Kennan through the minds of State Department and CIA officials and toward the democratically elected leaders of Iran, Guatemala, and Chile, most notably reified as containment failed abysmally in the Vietnam War of 1962-1975.
  4. The idea “All men are created equal” rooted in ancient Jewish wisdom and found in texts of 17th century English thinker John Locke influenced Thomas Jefferson and other Founding Fathers. Thomas Jefferson and Benjamin Franklin’s reading intersected with Locke’s actual role in the drafting of “The fundamental Constitution of Carolina” for his patron Lord Shaftesbury’s pioneer residents of Colonial America. “All men are created equal” has been a potent rhize whose power was manifest in the fact of the American Civil War.

Mythome-Part One ( JB neolog via Ferdinand Saussure and Roland Barthes,) As in Biome, Bacteriome, Virome i.e. the whole shebang of a given system – myth in this case. The dense fog of ideas comprising our shared consciousness. Our mythome is the entire realm of socio-religio-legal, ethical, moral-scientific, art-making, war-making belief, i.e. the three dimensional tangle of our shared existence as it is woven up, down and around and through Global Capitalism-banking-manufacturing-marketing and entertainment. The colossal rhizomic mat from which we try to derive a meaningful life is our mythome.

Mythome-II There is a grand game of musical chairs with worker exploitation as the empty chair. The music of profit-seeking plays, populations stir, protest, vote, elect, strike and the ogre rises and shifts to a new population. The filled chair is the nation most willing to allow the exploitation of its workers. From 1840 to 1862 it was the USA – South; today it is Pakistan, Indonesia and Mexico. Read the label on your T-shirt for the latest victim-nation.

Mythome-III The Capitalist world, after 250 years, is running low on victim nations and will look to the prison population of economically viable nations for its factory workers. Millions of prisoners will be sorted into two groups: the well-behaved pliable workers and irretrievable unfortunates who will remain in their cells. The prison labor force will work for 35 cents an hour building our cars, airplanes, appliances, brooms, and toys. By the year 2025 all factory work will be done by prisoners and robots. Asians and Mexicans will have priced themselves out of the market.

According to Deleuze, the rhizome has no particular beginning or end thus any power of place occurs at the intersection of two or more rhizomes or the place where one small rhizome hits a larger one. Imagine the dendrite of a neuron that has been untapped for the first 20 years of life, growing into and linking up with an old neuron in action since birth with its billions of connections throughout the entire nervous system connected to all sense and memory. In 1825 New York City already had been a vital american rhizomic link to Europe and the rest of the world for 150 years. With the completion of the Erie Canal in 1825, as NYC was linked to the bountiful heartland of America, New York City became a nodal point and rapidly developed into “The Big Apple” – a burgeoning metropolis of international scope. From bustling end point to globally influential node. Before the Erie canal, New York City was a rhizomic endpoint; after the canal it was a node on a mighty rhizome.

It is counterintuitive that a node would have more clout than an endpoint but it is the multiplicity of linkages at a node that generate power and influence. People who cultivate the most links with others thus making their dinner parties nodal events, make themselves powerful nodes in their political milieu. The artist plys his working existence in a studio or at a desk alone with his / her muse – isolated endpoints, whereas the savvy, influence-hungry journalist plays out his craft at vociferous dinner parties, raucous gatherings of influencers seduced by excellent cuisine, lubricated with lip-loosening alcohol, debating the future of America. This dinnertime as path to power trope is examined in detail in Gregg Herken’s book “the Georgetown Set” A potent slice of 25 years of American foreign and domestic policy worked out at such social gatherings in the homes Washington DC’s political players, from the CIA, the State Department and The Washington Post and other DC power centers.  

A playwright who directs his own work and that of others is at the intersection of enormous rhizomic energy radiating from other playwrights, actors, producers, set designers, newspaper critics, audiences. The chances of career development are multiplied geometrically from such involvement – see: Bertolt Brecht at early career when pivoting from starving unknown writer haunting cafes of Munich  to the hottest theatrical celebrity in Berlin, Germany’s largest city and capital. There is another rhizomic tangle at work as the playwright sorts through the work ( a variety of rhizes)  he/she absorbs in their local theaters, combined with poetry, plays, novels and political events not to mention one’s own hormonal allotment creating energy, anxiety and rebellion.

JB Miscellany:

  1. Writers forget that writing is the residue of thought and feeling and fact – it is nothing much itself.
  2. When a person says, upon returning from travels “I caught a bug in Mexico, Greece, Uganda, France, Siberia, wherever, perhaps they always carried that bug in their bodies along with ten million other species of microbe at work around the globe and in our bodies 24/7/365. It was their immune system that took a hit in said foreign locale due to lack of sleep, excitement, too much drink, airport stress etc. the bug was in them all along but dormant until stress set in to compromise immune system.
  3. History valorizes those who shock, not those who love. You love literature, you’ve read the canon and loved much of it, memorized dozens of passages and poems and written intensely-crafted poems and novels yet remain obscure with cash-flow challenges – shocked anyone lately? Adults consider the source when shocked – it is typically left to youth to be shocking, as adults tend to look stupid or crazy. Young people are expected to shock us in new and possibly constructive ways: see: Einstein, Picasso, Braque, Duchamp, Kirchner, Brecht, Warhol, Schnabel, Basquiat. The delivery system of  shock is typically an outsider struggling to come to grips with a corrupt establishment. Mature adult artists get the big picture and make a living serving the beast ( Global Capitalism) in one way or another, teaching, selling insurance, writing ad copy, doing corporate architecture ( isn’t all architecture corporate or one degree of Kevin Bacon removed?) . You did your shock and awe phase during your wild, wooly twenties when no one was looking. Note to artistic self for next life – go to art capital, duke it out with less shocking-destructive peers and prevail for patronage, fame, wealth and the history books.
  4. When early 1950s foreign policy guru George Kennan’s “Containment” philosophy ( contain the Soviets) slowly and painfully morphed from push to shove in Vietnam during JFK’s 1960s, the Containment trope disintegrated as an ugly, stupid, contagious frog got boiled in the jungles of South Vietnam, revealing its wormy, rotten essence i.e. contain until it gets difficult then just let ‘em run all over you – who will care? What’s so bad about Communism anyway? The Vietnam War shed a harsh light on Kennan’s big idea from the beginning of U.S. involvement ( JFK’s 20,000 troops). Containment was unprincipled at its core thus not worth fighting and dying for. Containment was nebulous, too abstract and it involves policing state ambition not defending one’s land / honor / founding Enlightenment principles of life, liberty and property. Containment, at its root in Vietnam, was always a violation of our deepest principle of sanctity of property. That American policy makers would give a damn whether Vietnamese become communists or receive aid from generous neighbors (Chinese) was always secondary to our hallowed first principles stated so clearly by Thomas Jefferson in our “Declaration of Independence” Sixty thousand U.S. soldiers dead – what a fucking waste serving a rotten rhizome that wormed its way through the consciousness of The Georgetown Set from 1950 to 1975. Bobby Kennedy put it best: “Jungle Rot”
  5. We live in a culture of leftovers – Commodity Capitalism. Mechanized societies with global rhizome networks of trade do the killing, thieving (of land and health) we make the laws that suit us, valorize the philosophers who explain us, sanctify the religious leaders who give us the moral go ahead. We defend the trade routes and finance all of the above. You – the world’s 90 percent slave in factories, as juridical bureaucracies ensure that you keep your mouth shut, work hard and go to church, reaping your small benefit from menacing paternalism.
  6. According to Yale professor emeritus of Literature Harold Bloom author of the iconic text for all creative types: “the Anxiety of Influence”, every writer of note wrestles mightily with poetic precursors, for Bertolt Brecht his primary “foes” were Rimbaud, Baudelaire and Verlaine. Brecht’s “B” team was his immediate  precursors  Richard Dehmel, Detlev Liliencron, Otto Bierbohm and the metaphysical clown Karl Valentin. These men were as Woodie Guthrie and Alan Ginsberg to the emerging Bob Dylan in the early 1960s. Valentin was the cudgeled hero ( see: Charlie Chaplin)  trickster – the Apollinaire of Munich, melancholy clown.
  7. Cubism, Dada and Expressionism were the youth movement of a new, 20th century. Interesting that they are visual arts whereas the youth movement of the 1960s was dominated by music, perhaps Pop Art was a youth movement of pre-boomer generation.
  8. The shark was a recurring motif in the work of Brecht: see: “Mack The Knife”
  9. Compare and contrast Bruckner’s “Wozzek” and Budd Schulberg’s “On the Waterfront” the “I could’ve been a contender” theme.
  10. Brecht strikes one as an All-American ( though German) intellectual-artist-cowboy. Brecht loved America and the idea of the natural man as opposed to romantic man. Natural man is of the Earth not of the spirit. He is sweat, snot, blood, guts, semen, tears, sex, fist-fights, wrestling, eating, running, smoking, eating more, rebelling, bitching about the bourgeoisie – those slightly older folks locked into the Capitalist mythome trying to make a living.
  11. Might perforin ( pre-forming protein) release be a mechanism for branching in trees?

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March 10, 2016    7:52 PM

 

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Squirrel Factor

 

When living in Palo alto a few years ago I could look out my home-office window and see a squirrel scurrying along a 2 x 6  fence rail. From time to time I would put a peanut or two on this rail and watch the squirrel stop, sniff the peanut, grasp it, quickly gnaw into it and either sit there and eat it or quickly carry it away. One day I put a small pile of peanuts on the rail – a treasure! The squirrel ran up to the pile, took one look and without taking a single nut, turned and ran away. I tried this a few more times. Whenever there was more than a few nuts,  the squirrel would run off without taking a single one. What was it about the unexpected and un-natural  bounty that frightened the little guy? Did too much of a good thing signal doom? Was this squirrel hard-wired to distrust excessive good fortune? Was it the weirdness of too many nuts in one place? A squirrel is a mammal. Humans are mammals we share 95% of our genes with squirrels and we share this revulsion toward unnatural, unexpected goodies.

On the night April 22, 2014  62 year old British aristocrat and passionate animal rights advocate Mark Shand fell to the sidewalk in New York city and died after a night of celebrating a hard-fought victory in his battle for Elephant protection in India. A dear friend Barbara Kwiatkowska said “It was a night of triumph and Mark was so happy. this was his big night, you could see how happy he was.” Mark’s foundation “Elephant Family USA” had just raised $1.7 million at a charity auction at Sotheby’s. Mark had been drinking scotch from dinner until he walked out of his third establishment of the night (“It was scotch all the way”) for a cigarette at 2:00 AM. Mark walked into a revolving door after finishing his smoke and fell back to the sidewalk, hitting the back of his head this time, cracking his skull and bruising his brain – he went into a coma and died the following day, to the shock and sadness of his family and friends. He was in the prime of his life, a “lion” to his closest friends.

What happened to Mark? Why do people drink to excess when celebrating big victories? why do auto racers celebrate a big win by ritual spraying of champagne onto all around the podium? Why is the victor presented with a magnum of champagne in the first place?  There is a tight link between victory and alcohol in our culture. Why?

Answer:  Squirrel Factor

Mammals are hardwired to distrust excess in good things. Alcohol depresses feelings of bliss associated with triumph. Your close friends will ensure that you drink a lot after a big victory. They will accompany you all over town as you drink yourself stupid, bringing you back into the orbit of the normal. Your friends don’t want to lose you to the bliss angels.

Jimi Hendrix was the towering master of rock and roll in 1969,  admired by his colleagues and worshipped by millions of amazed fans. He drank to excess one night and choked to death on his vomit. Mama Cass, Janis Joplin, Jim Morrison-ditto. Kurt cobain blew his brains out at the height of his global success. !00% of touring rock stars of the past fifty years are drug and alcohol abusers – why? John Lennon- heroin junkie, James Taylor-heroin junkie, the Allman Brothers and their entire road crew – heroin junkies. One might think that musicians who have arrived at “The Mountaintop” (global success: worldwide sold-out concerts, international #1 hit records,TV appearances) would be high on a sort of natural happiness from having finally achieved a hard-won goal but they appear to be lower than people not dealing with fame. The mountain top breeds addiction like a Guatemalan swamp breeds mosquitoes. Look at a photo of the Beatles in 1970 after seven years of unprecedented acclaim,influence, towering personal wealth, love, adoration and respect from all corners of the cultural landscape. Faces as unhappy as those photographed overlooking a mass burial pit at Auschwitz.

Squirrel Factor – mammals (reptiles, amphibians, birds?) have little capacity to endure bounty in any form: love, money or fame. It just ain’t natural. It makes people nervous. It makes one vulnerable – to what? jealousy? envy? mooching relatives? The inevitable bliss-crash? The successful  have become tall poppies. If society doesn’t find a way to bring us down, most of us will find a way to bring ourselves down. This is quite sad.  Strength of character is measured, not by one’s capacity to endure hardship – almost all of can handle hard times, character is measured by one’s ability to endure bliss, to remain in the flow,  to savor victory in a graceful, non-destructive way. To live day after day in an elevated state i.e. to be happy.  Savoring victory with intelligence rather than in an alcohol stew is very hard for most.

We treasure our stories as they are  workable, exchangeable, elastic excuses for marginal ascent into one’s zone of excellence and happiness. Our stories are our reason why not. Is it Western culture alone that forces one to apologize for success? No, Russians drink like fish to avoid bliss.  Is bliss-killing an American, British, or uniquely Protestant, Christian or Muslim thing? Yes x 5. Whatever the biological or cultural origin and scope,  It is an unfortunate tendency that must be battled daily. try to endure an extra minute of pure happiness each day. Strengthen your bliss. Don’t follow your bliss. following implies that you are its dog. You and your bliss are one.

Beverage alcohol is a $200 billion industry in the United States. That is 9.4 billion gallons of bliss-killing slosh n’ grog across the land. We call ourselves the home of the brave – Ha!  The home of cowardly beer-swilling  bliss-chickens. Squirrel factor is an instinct. It is hardwired into the animal brain. One must battle it daily.

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JB Questions and Observations: Books: “Empire of Cotton”-Sven Beckert, The Georgetown Set” Gregg Herken – residual thought at item #1 from “Elementary Forms of Religious Life” – Emile Durkheim

  1. Picasso appropriated indigenous, timeless African and Polynesian totemic motifs, sacred religious objects, images, talismanic relics for his urban, boho-bourgeoisie, art-as-commodity milieu. He took art with deep tribal significance and repositioned it, appropriating all things bold and strong from this native art while conflating it with the rebellious pictorial tropes of late Cezanne ( more mythically dynamic art) in order to begin the path toward Cubism in 1906 creating his Tropes de Tropique ( JB neolog) that evolved into “Les Demoiselles D’Avignon” in 1907 followed by  full-blown analytical cubism in 1910 “Portrait of Fanny Tellier” and the synthetic Cubism ( collage) of 1912 that has inspired architects for 100 years.
  2. JB Theory: Low oxygen levels above 10,000 feet altitude in a small plane cause neurons to burn fat giving a sugar high euphoria and impaired judgement. Pilot to himself “Running on fumes – no problemity I can make it 200 more miles to Boise”
  3. JBQ – does oxygen-sensing in the vertebrate brain have a link to bacterial activity?
  4. At “Empire of Cotton” JBT – Along with the exit of USA manufacturing to Asia, Indonesia and Mexico, there is little incentive to maintain infrastructure in USA for citizens alone. Infrastructure is for capitalist enterprise and the defense sector that enables it – the people just tag along on fine highways, port facilities, utilities. this explains the rot of USA infrastructure as capitalists and their congressional handmaidens put money in international banks to be spent on foreign infrastructure development in third world where their businesses are located.
  5. At “The Georgetown Set” – Herken JBT – Pundits, policy wonks, politicians of the 1950s were all alcoholics thus always depressed, no wonder the Cold War took root. See: Alsop Brothers, CIA directors. All of Washington DC was pickled – maybe it still is.
  6. We need a minimal letter symbol such as the “etc” or “et al” that means “and later” example: Brits invested in agriculture in USA during antebellum and ( plug in new abbreviation here meaning and after.) Perhaps “altr” short for and later.
  7. JBT – whatever causation is at work when one makes a decision during artmaking is the same as the urge-compulsion at work in a metabolic process at the cellular level.
  8. Throughout the 19th century the northern states and the Brits were deeply involved in the entire business of cotton growing, ginning, shipping and remained involved after the Civil War as owners, agents, bankers for coal mines, quarries, railroads so – for slavery as well as for slavery by another name. Coercion of African Americans from nation’s colonial beginnings to the middle of the 20th century. Emancipation of slaves generated a second round of moneylending to small cotton farmers i.e. loans were refreshed. The Brits may have outlawed the slave-trade in 1807 but the steam-driven  industrial revolution in Britain was built on the backs of American slaves.
  9. Sociocultural rhizome ( see: Gilles Deleuze) at work in Washington DC during the Cold War: 1. Joe Alsop writes a column on the missile gap between Soviets and USA 2. JFK reads this newspaper column into The Congressional Record on the Senate floor. 3. Alsop mentions JFK in two of his following newspaper columns as an American leader with foreign policy acumen. 4. JFK rises in nation’s consciousness becoming part of the zeit.

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February 29, 2016    5:18PM

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Bacteria Barbie

 

Humans do not dominate the planet because of our clever tools or our art and science but because we have been able to enslave one another and build relentlessly on this control over our own species. – JB

Each human harbors ninety trillion bacteria. This is ten times the total number of human cells present in a body.  There are 7.4 billion humans on Earth, 7.4 billion times seventy trillion is a large population. The total human population is a rounding error in relation to the total number of individual bacteria. The total population of all multi-cell animals including insects, mammals, reptiles, amphibians, fishes and birds is a rounding error in the face of this colossal microbe population. The majority of Earth’s biomass comprises microbes.

Think of a naked Barbie doll as the kingdom of bacteria and each of 8 million  species of animals as one of her outfits. One costume per occasion / ecosystem. Humans are only one of these 8 million. The signal feature of the human costume for Bacteria Barbie is our multi-folded neocortex. The complexity ( number of folds)  of our neocortex is the only physical characteristic distinguishing humans from most of the hundreds of other mammal species,  all of which have elaborate nervous systems-brains. You can find every brain area possessed by humans in a killer whale, dolphin, chimp or a mouse. Our neocortex has more neurons packed into six layers and a multitude of folds, though total mass of the human neocortex is smaller than in several large mammals. Sperm whale brain: 8,000 cc, human brain: 1,300 cc. Human brain surface area: 2,275 cm squared  bottlenose dolphin brain surface area: 3,745 cm squared. Human neocortex has six layers of neurons, dolphin and other large mammals only five thus the greater brainpower in the realm of society-building, social interaction.

JB Theory: Our human bacteriome has a consciousness that has evolved over three billion years that has directed its evolution and all higher animal evolution for the past 1.5 billion years.

Example: Each of us has 45 trillion bacteria in our gut, some of them initiate the feeding cascade. Bacteria get hungry, sending signals to ghrelin and glucagon molecules in the stomach causing pangs of hunger signaling afferent neurons through the spinal cord to our thalamus and hypothalamus in the brainstem. The hypothalamus sends an array of hormones through the brain, head and body that prepare for eating. When gut bacteria are sated they initiate the leptin cascade and we stop eating.  All animals are either eating or making plans to secure food ( working 9 to 5 at office, pumping iron at the gym) every waking hour. Not much animal behavior is more than one “Kevin Bacon” degree from eating. For the first 4.5 million years of human existence we spent all day hunting and gathering (gathering is hunting for nuts and berries). Today hunting takes myriad forms but it’s all hunting. Humans are directed by our voracious bacteria to hunt all day and into the night.

To do: Identify the chemical and or electrical signals  and inter-bacterial electrical networks using membrane filaments as pathways and antennae between gut bacteria and ghrelin hormone ( eat) and for signals between leptin and gut bacteria (stop eating-you’re full).

JB Questions and observations: ( reading: “Empire of Cotton” – Beckert)

  1. Both South Asians and Native americans were colonized by Western Europeans. why were Native Americans obliterated and South Asians not?  Was destruction-causation all microbial?
  2. Does ethanol ( Whiskey, vodka, gin etc.) damage survivin molecules in the human gut epithelial cells thus exposing intestinal tissue to microbial harm? “Survivin is a key regulator of gut tissue integrity as it regulates epithelial homeostasis in the stem cell niche.” – Martini et al
  3. Britain and Boston financed and manufactured cloth made from cotton grown by one million American slaves they so vigorously lobbied to “liberate”  “Lords of the loom and lords of the lash were tightly linked.”see: “Empire of Cotton” by Sven Beckert
  4. Did slaves build the railroads of the American south between 1830 and 1861?
  5. Andrew Jackson is to global capitalism what Isaac Newton is to classical physics. Jackson was the “Key Man” as he initiated the core capitalist cascade of 1.  Land appropriation by coercion at American South  2. Cotton growers moving into this incredibly fertile-suitable land, displacing Native Americans, to grow high quality cotton. 3. USA cotton grown by slaves fuels the Industrial Revolution in Britain and across the globe with high quality cotton for distribution to European textile mills at ever lower prices. Andrew Jackson was the paradigm shifter from War Capitalism to Industrial Capitalism. He should not only remain on the twenty dollar bill, his portrait ought to be enlarged and printed in four colors.
  6. Was there a strong relationship between the French blockade of British trade from 1806-1814 and the War of 1812 in USA?
  7. What were the health effects of calico printing dyes-inks on Europeans during the 19th century rer: ink-immune system integrity-gene damage via skin absorption?
  8. If a liver cell ( hepatocyte) was the size of a football field in height-width and depth, a protein molecule would be the size of a snowflake.
  9. Proteins are synthesized at ribosomes dotted around the rough endoplasmic reticulum (RER) that surrounds the cell nuclear membrane.
  10. Does a cell nucleus migrate within the cell volume so that it is nearest the zone of outer cell membrane that is closest to the nearest capillary for the transport of this cell’s protein products to other areas of the body? It seems that the vacuoles transporting these proteins from the RER to the outer membrane would want to traverse the shortest distance across the volume of the cell and avoid dodging unnecessary organelles and vacuole traffic.
  11. How does a cell nucleus detect the nearest capillary so that it can shift toward it? Electromagnetic signal via iron-rich proteinic “wires” extending from outer surface of cell membrane-nanostructures?, wireless chemical signal?, smell, taste, touch?
  12. Sven Beckert, in his book covering the roots of global capitalism asserts that there are two phases to Capitalism: War Capitalism where European absolutist states conquered indigenous people and one another to expand and control markets followed by Industrial Capitalism characterized by harnessing steam power, economically and legally coercing proletarian labor  and enacting laws that shifted land from difficult to manage communal ownership to private ownership enforced by law. 1.  Kill-’em ( “others”) -steal their land, 2. Enslave your own people literally or figuratively with backbreaking, mind-stunting, soul-killing factory work and one-sided credit schemes.  Beckert asserts that War Capitalism occurred first and paved the way for Industrial Capitalism which has thrived from the late 18th century until the present. These have been occurring simultaneously all along. The two capitalisms are an ongoing duality – subparts of the overarching capitalist project.
  13. What is the smallest box of Crayolas that will deliver an orange crayon? Twelve. what is the smallest box of Crayolas that will deliver a chartreuse” Sixty-four.
  14. Individual freedom implies a gradient between the individual and his / her nation. Global capitalism, over the past 250 years has burgeoned because it has been and continues to be an extremely efficient gradient reduction engine. Capitalism reduces all things. It has reduced the inherent-latent and expressed power of the free individual as all of those in a capitalist culture are enmeshed in its machinery of work-debt-spectacle-myth-habit. Capitalism is a gradient reduction engine. Capitalism’s great convection sucks free young people into the abyss of capitalist wage-slavery-credit-workaholism where they try to remain afloat in its unrelenting, faceless turbulence.
  15. One of the larger failings of Christianity was to remain silent  during the 19th century as three generations of European and American children were lost to brutal work in textile mills. And adding to this cowardice is a toxic ecumenical ethos centered around a work ethic, the inevitability of work, as if any animal would think otherwise about slaving from dawn to dusk for subsistence. Christian apologists who watched this unfold remind me of the American doctors who gave their stamp of approval to continue deadly below surface work on The Brooklyn bridge as hundreds of men died agonizing deaths from nitrogen narcosis after shovelling mud and sand deep under the river within 60’ x 60’ caissons.
  16. Regarding networks – power lies at intersections not at the terminals.
  17. The entire Industrializing-colonializing world was dependent upon American Slavery in the 19th century prior to The Civil War: England, France, German Lands, Belgium, Switzerland, Greece, Egypt, Turkey and India
  18. Capitalists have lobbied with vigor over centuries for government intervention, for wars against indigenous people, railways, highways, port facilities, land laws, contract laws, shipping protection and tariffs. They shout whenever the government spends money for social well being for the other 95%. They aggrandize themselves as independent, self-made, prudent, ad nauseum. Capitalism has always been a one-way spending street whose motto is: remove, enslave, suppress, coerce, dominate.
  19. Multicell life evolves as a more ferocious entropic gradient reduction system whose greater complexity ( than single cell prokaryotes) enables quicker solar energy dissipation.
  20. What role have microbes had in evolution? The symbiosis of energy producing mitochondria with early bacteria was a significant breakthrough opening the door to multicell life able to burn a lot of energy.
  21. Do gut microbes use the central nervous system pathways to communicate with the brain?
  22. Do gut microbes exist in a caste system with long-term resident species electrically interconnected with nanowires that can signal within an entire population of bacteria and that can also signal the brain? Are lower-caste microbes ones who ride out by the billions on every turd? Is microbial life democratic or absolutist?
  23. Might a person contain bacteria that were also present in medieval ancestors?
  24. If gut bacteria grow electrical filaments, how long does it take for a next generation to grow its new filaments?
  25. Are there bacterial filament electrical networks that live as long as the person and that expand as the person ages and the microbe population grows?
  26. Might one’s internal organs get tangled up over time with bacterial filaments like an overgrown, clotted root system in a small flower pot?
  27. One word: Electromicrobiology

***

February 23, 2016    9:22 AM

 

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Rejection-Creation

 

In 17th century Fiji there is a tribe of ocean-going navigators in which the young men learn to sail around the island group fishing and exploring. The islands have gotten crowded, the habitable land and the marriageable women are spoken for. There is no room on the islands to give the young men so that they might start families. These young men are rejected by their society. They rig up ocean-going sailing canoes and set off in search of a place beyond the horizon. Young men rejected at home create a new society in the vacant ( of humans) Hawaiian Islands. Rejection has initiated a cascade of creation.

A songbird chick hatches and grows to maturity with an unusual tuft of feathers on its head and three others of her age-mates develop misshapen beaks. These mutants are unlike any other birds in their forest. They are rejected. They fly away together to a different forest with insects burrowed into the bark.  A new species evolves with a beak good for bug-killing and a distinctive and respected tufted head. This new species thrives. There are two forces at work here causing speciation: an initiating mutation and the demands of a new environment. The emergence of this new species is the result of a “Creation Cascade” ( JB neolog) 1.  The initiating mutation-misfit-misalignment  2.The exit from the tribe-clan-flock 3. The adjustment to the new eco-opportunity and its inevitable adversity.

External – Dispersion from conflict,  persecution, famine, war= external cascade

Internal – Dispersion from constriction: 1. mammal birth – fetus too large-rejected by mother’s body-new life emerges 2.  one’s goals become too large for current work role i.e. insufficient creative outlet – seek more challenging job.

Rejection in romance has been one cause of 3,000 years of literature, art and music. The act of rejection creates a platform for creativity. rejection creates a void that is often filled with art or other drugs. Art is a drug, drugs are not art.

Rejection-creation occurs at different levels of our social taxonomy: 1. One on one at romance, workplace, social club. The act of rejection plants a seed or perhaps unwraps a zone of  your DNA for transcription-translation into a new protein – a new way of walkin’ 2. The group rejects the individual – this happens 10,000 times a day in schools across the land – social sorting. Birds on a wire pecking and pecking until three fly away and start their own club with its own rules. The Beatles were a small, very tight club – a cultural sabot – an armor-piercing projectile that blew up the whole ammo dump of congealed post Elvis, pretty boy from Philadelphia, pop music along with the hearts and minds of the Boomer generation.  Sabot-savants: Dylan, Simon, Hendrix, Morrison. The song as a sabot penetrating hearts and minds.

A creative person rejects 100 ideas for every keeper. the creation of a work of art means rejecting all that is tired, trite, timid, trivial, treacly. All that is not fresh is rejected and this is creation.

Education is learning what to reject during your exploration-investigation-experiment. No need to re-invent any part of the car, much less the wheel. there are 50,000 parts to a car. It will take a lifetime of study to know the important ones. Learn the terrain, touch and go – move on if the territory has been explored.

Rejection and creation are yin/yang, positive-negative space: the S-holes and the S   ( see: Bakanowsky). Rejection and creation are two sides of the same coin. Where there is rejection there will always be creation, latent or active. Nature frowns on a vacuum. Rejection creates a vacuum in the soul that will be filled. One might as well give this vacuum-filling direction. Nature, when left to itself, will ruin things. We see beauty in the animals, plants and landscapes all around us but these manifestations of Cosmo’s glory are the tip of a deep pile of evolutionary debris from eons of undirected agency – see: Charles Darwin.

Latent Creation:  (JB neolog) The unexplored psychic bomb – example: Adolph Hitler, though a talented painter in a sublime but traditional manner, was rejected by the art community of Vienna, a hotbed of all things modern at the time, especially painting. An opportunity for creation was planted in Hitler’s psyche by this rejection. How his “creation” played out is history but at its root was rejection. Hitler’s life in the trenches of WWI were also a rejection of all things good. Joseph Stalin, late Czarist Russia’s most famous young poet whose creative roots may have been boyhood beatings or his four trips to Siberian villages as a political exile. ( Were Czarist forces grooming a mole?) How many bullied boys develop notable creative energy?  Every boy gets bullied – it comes with boy territory though it may seem special at the time. Where you see rejection there is creation.

If you are the rejector, expect creation blowback, often ugly. If your group has rejected others by code or by act – expect a creative response. remember that the creation following rejection is as likely to appear destructive as constructive. Terrorism is creative blowback. The Western world is fortified top to bottom, from the nuclear triad ( Bombers, missiles, submarines) to our militarized local police and well- armed next-door neighbor. The USA has done a lot of rejecting in 250 years and instinctively, methodically, obsessively arms itself in expectation of some inevitable creation. Rejection is creation is destruction is terrorism.

What artist ever brought more sublime terror upon a tired art paradigm than Paul Cezanne. Cezanne’s creation, his proto-Cubism was the Beaux Arts Academy’s destruction. It happened as follows:

  1. Cezanne is refused by the French art establishment early in his career.
  2. Cezanne, with his hearty diligence, creates a deep new way of picture-making
  3. Cezanne’s creation inspires the destruction of the French Academy  as his acolytes Matisse, Picasso, Braque and Duchamp shift the Art paradigm for the 20th century.

The Law of Rejection-Creation: Rejection and creation always work together. They are a duality. They are always together like white on rice, like stink on shit.

Corollary to the Law of Rejection-Creation: One cannot revisit the site of a rejection event to unring the bell or to put toothpaste back in the tube. If the bell has been rung, if the tube has been squeezed,  be on the lookout for creation in manifestations good or evil. There is no indifferent creation. Rejection often grows to maturity, ages,  festers, incubates. Sometimes the creation ( destruction?) response is immediate but creation is often a dish served cold.

Synonyms for Creation: formation,conception,genesis, inception,origination, origin

Synonyms for rejection: elimination,exclusion,repudiation,refusal, surrender, alienate

A person or group will reject a member for becoming unlike them or a membership candidate for being unlike. Western societies pay lip service to uniqueness but turn their backs on it. We celebrate the prominent who have risen to prominence through talent, original thinking, hard work and luck, then we reject them. We cut all tall poppies – perhaps for their own sake, for it is “lonely at the top” a lie of course.

Rejection? why do we reject? Is it jealousy, envy, scapegoating, social difference re: education, net worth, speech, family heritage, illness, age, smell, sight or touch? All senses and memory has its say in the act of rejection. I reject my under-actualized self in order to search for fulfillment of my destiny.

The shock of rejection. the instant void – alone, cast into the cold creates a bubble within the heart and mind to be filled with wonderful things or with destruction. One becomes “Other” by rising above the group or falling below the group. soaring or sinking at all times: Personal convection ( not conviction here) The community occupies the middle ground. We must use our wings with skill to stay aloft.

Action-reaction. The act of pushing out a person propels one backwards. Push too hard and find one’s self afloat in the void. See: New Jersey governor Chris Christie, Republican presidential candidate humiliating fellow presidential candidate Marco Rubio, pushing Rubio out of contention during February 6, 2016 nationally televised debate and finding himself, Christie,  damaged goods in New Hampshire primary voting the following week.

Rejection: Elapsed Time: If an adolescent rejects a parent sixteen years after this child becomes a member of the family, there is a different dynamic at work than during more rapid rejections such as  failing to fit in as the new kid in school.  The time “in country” is proportional to the scale of the vacuum created after rejection. The hardening of the surround makes the void less elastic, more difficult to fill. How might one induce plasticity into a hardened mental-physical habit or expectation so that the interior surface of one’s emptiness might conform more quickly, or at all to a new idea-process-endeavor?

Much anxious energy presently manifest in the spectacle of daily life and ritual in the U.S.A. is rooted in nervous anticipation of  latent effects of unexplored, unexpressed creative opportunities of displaced Native American’s and formerly enslaved, currently harassed African Americans.

Rejection and creation are one.

February 10, 2016   2:17 PM

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Fogify-Clarify

All science writing is full of holes because all human thought is, by its nature,  full of holes: unproven, unprovable assertions i.e. Russell’s Teapots. Durkheim, Freud, Jung, Levi-Strauss, Stephen Jay Gould,  using the Torah as a model, weave porous rhizomic webs comprising much research of others, adding their own notes and many bold assumptions/conclusions hoping that their assembled compilation of myth hits a nerve, in the community.

Myth: An association of ideas reinforced by habit.

Mythics ( JB neolog): All culture including all tradition, history, rite, ritual, religion, all language, science, law and belief as expressed in architecture, books, music, worship, all ongoing interrelations between and among all people engaged in all things. The entire ball of uniquely human wax – the big rhizome – the swarming, teeming, rising, falling nest. Mythics can also refer to a specific culture’s “whole ball of wax” as in American mythics or Aboriginal mythics. Mythics includes myth and religion and science. In biology there is Darwinian mythics referred to as “The Grand Synthesis” or the Genetic mythics encompassed in the term “The Central Dogma” We need a word that is more inclusive of myth or zeitgeist or weltanschauung or culture or society. Mythics. There is family mythics and personal mythics ( see: all memoir)

Mythics is the Kool aid you are given to drink and that you ingest / absorb in 10,000 different ways throughout life about how your society functions. Every parent and every profession has its mythics.

Fogify: Intentionally obscuring the matter at hand to prevent others from seeing deeply into one’s assertion. see: smokescreen

Clarify: Assembling the fog of others in an effort to explain one’s own fog. Foggy thought is amassed in plain enough language to make a case. Who’s to say otherwise? These days, who could possibly care? No one has the time to re-read their own fog let alone verify the fog of others. If they see a mark of membership in whatever priesthood ( usually a PhD)  it’s live and let live. throw your ideas in the pot until someone cares enough to argue.

Sfumato: The atmospheric reduction of the intensity of distant hues and tones. Green foliage looks blue and dim in the distance due to the effect of the atmosphere. Air filters yellow wavelengths of light from the green wavelength from trees, leaving blue.  Leonardo Da Vinci used this popular renaissance picture-making in the background of the “Mona Lisa”.

Blake’s Law: Understanding diminishes with the square of the distance from the matter in question. Corollary One: Understanding increases with the square of the distance from the matter in question.  Note One:  You can’t know the forest if you don’t know the trees. Note Two: Knowing trees while losing sight of the forest is to lose context and thus, meaning.

In his towering novel “The Structure of Evolutionary Theory” Stephen Jay Gould fills 1,300 pages trying to shift our understanding of core aspects of Charles Darwin’s theory of species evolution. Gould’s research and reasoning  weakens two of three of Darwin’s core arguments for species evolution. Gould’s achievement is  monumental but it makes him appear a cheeky upstart.  Gould generates 1,000 pages of intensely interesting ( though repetitive) historical and contemporary fact, figure and anecdote to fogify his achievement, to demonstrate obeisance to the big chief of all bioscience and all contemporary culture.

Darwin, the biggest paradigm shifter of our epoch, remains foundational in 2016. Gould hasn’t made a dent. To  try to rattle our core notions at this point, no matter the fecundity of one’s facts and figures perhaps gleaned from decades of diligent research, gets little traction. Scientific community to genius upstarts: “You’re all brilliant, probably right, now go away.”  Darwin, like Christianity, is bigger than science – he is our culture. He is untouchable. If Darwin goes, it all goes. His thought is a taproot of the rhizomic network of myth propelling our belief system. Diddle with Darwin at one’s own risk, even if you have a customized, two piece pool cue.  If Gould’s magisterial book had been published within 50 years of Darwin’s Earthshaking tome “On The Origin of Species”  Darwin would be a footnote rather than a foundation.

In his iconic book “The Elementary Forms of Religious Life” Emile Durkheim asserts that all religions share a few principles whether remote aborigines or urban judeo-christian sophisticates:

  1. A sense of sacred / profane, a belief that a man comprises a sensate and a spiritual being, mythic personalities
  2. Totemic representation of the sacred as well as the negative cult ( see: The Devil @ Christianity)
  3. Rites of initiation, rites of grieving,  gathering at regular intervals to celebrate clan / tribe/family identity, the tribal bond, hopes for good fortune,
  4. Acknowledgement of an overarching cosmic power-deity-god, a sense that each clan and each person contains a part of this power.

Durkheim asserts that both science and religion are products of belief. Society dominates all ideas sprung from the human mind:  scientific or religious. Durkheim asserts there is nothing beyond society, nothing greater than society and that individual thought and will is formed, judged and subsumed by society that religion is not primarily about the cosmos, the unknowable, the forces of the universe but about binding populations. “The believer is raised above his condition as a man thus gaining strength as he is saved from evil in whatever form evil may take” -Durkheim

Durkheim asserts the primacy of abstract theories/ideas above individual works as being more true. Durkheim, in studying (second hand) religious patterns of aboriginal tribes of Australia projects his discoveries among them onto all religions worldwide. He has entered his project with the full array of late Victorian prejudice regarding the inviolability of human progress, social evolution/ranking: aborigines are primitive (black skin)  Native Americans are less primitive ( redskin) and judeo-christian people most advanced (white skin). It is no small irony that Durkheim takes 350 pages of detailed ethnographic description to tell us how “primitive” Aborigines are. They are, of course, not primitive at all.

Much of Durkheim’s fog comes from outdated Victorian ideas distilled from misreading Darwin about evolution and fitness. Additional fog comes from his judaic notions of the primacy of the group over the individual and the co-equal place of science and religion.  Durkheim-Fog has roots in his Jewishness, his Darwinness, his Europeans-as- privilegedness. Nonetheless his book has great value due to his detailed discussion of components of religious life. Whether his ideas are right or wrong 100 years after their writing is beside the point. Durkheim’s assembled rhizomic mat of ideas has value even if every bold assertion can be contradicted. This is the beauty of fog. Fog has value – it can dim the harsh glare of rational thought, contemporary prejudice or logical examination to reveal a deep truth about people.

***

JB Questions-Observations:

  1. The Churinga is an aboriginal totem meant to inspire collective feelings of respect. Are the “Mona Lisa” “The Pieta” such totems for Christians? Is a Gothic cathedral a totemic space / structure?
  2. Cartesian Principle asserts that knowledge can only be established link by link on “indubitable first principles”  This Cartesian idea fully contradicts the way the human brain establishes knowing via its myriad strand rhizomic network.
  3. Does the contract have totemic status in Anglo-Euro life? It does if Capitalism is our religion if we have sacralized it.
  4. Renaissance Popes used the profane seduction of Raphael’s Madonnas and Borromini’s sexy sinuous architectural space in order to win back into the fold of the mother church souls lost to the Protestant Reformation. See: Counterreformation.
  5. Durkheim tries too hard to separate the sacred from the profane. His rhizomic thread snaps from too much cognitive dissonance. He fails to establish a thread, a string, a filament on which he could weave further assertions experiencing “Rhize-Fail” JB neolog i.e. The untethered rhizome of one’s argument.
  6. Charles Darwin pulled the intellectual roots out of Christianity to little effect. Few cared,  Christianity was never an intellectual enterprise anyway. “Faith is impervious to experience” – Lucien Levi-Bruel
  7. What religion were Muslims prior to 8th century?
  8. What is the correlation between protein acetylation and folding to protein function at cochlear hair cells?  Does the protein’s folded geometry correspond to the afferent pitch signal distinguishing 500 different pitches?
  9. To investigate:Cortical and sub-cortical Interneuron microtubule networks that augment electrochemical links via axons-dendrites-synapses-neurotransmitters. Is there a family of signalling proteins that travel from neuron to neuron via tubules? Perhaps initial sensation and motor response occurs via traditional axon-synapse mechanism followed by long-term physical networks of tubules that carry chemicals faster. Does an axon become a tubule? Does the myelin sheath fuse into a tube once electricity is not the signaling mechanism? Do neurochemicals take over from electrical charge or vice versa?
  10. Durkheim proposes society as the the source of the idea of the ideal rather than  innate individual consciousness. This is not so. Most humans, most mammals have an innate sense of proportion – it is key to mate selection and to esthetics in general throughout the arts.
  11. Durkheim’s foggiest assertion is that the root of religion is in the collective not in the self.
  12. Another layer of Durk-fog is his valorization of the concept at the expense of individual expression and in so doing marginalizing all artmaking.

 

“Everything in social life including science, rests on opinion”

                                                                      – Emile Durkheim

February 2. 2016   5:50 PM

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Becoming Species

“There is religion when the sacred is distinguished from the profane”

– Emile Durkheim

Humans resist states of being at the heart of evolution: separation, isolation, freakishness, outlying but new species are born of weirdness, cataclysm, getting lost, change, mutation of molecule, cell, body, local environment and ecosystem. When the Earth moves – animals and plants evolve.  Continuity and comfort means equilibrium, balance, regularity, harmony, sameness. Nature does not embrace change unless change is vital for survival. Our nucleic acids battle efforts to change them 24/7. Most of this DNA / RNA change is bad and almost all is edited out of the genome prior to inheritance.

A species is a group of organisms that interbreed. Robins don’t interbreed with cardinals thus- two different species. Japanese people can and do interbreed successfully with caucasians thus they are the same species. All humans are the same species and there is only a single one-Homo sapiens. There are over 800,000 species of beetles, 20,000 species of bony fish.

Species evolve when and if they must otherwise they do not evolve. Species maintain their equilibrium over eons. A mosquito of today is almost identical to a mosquito that pestered the dinosaurs. There has been no evidence that a single higher animal has evolved in any way since Darwin published “On the Origin of Species” in 1861. Evolution, when it happens, is almost always abrupt on a geological scale, intensely slow in human terms.

Niles Eldredge and Stephen Jay Gould proposed their theory of Punctuated Equilibrium in 1974 asserting multicell organisms ( non-bacteria, non-virus, non-archaea) evolve when confronted with large environmental change such as an ice or heat age, grand geologic shifts-new islands and continents forming, a meteor impact’s negative effect on the atmosphere. This punctuation may take ten million years to play out giving rise to new species then stasis returns to this species for 100 or 500 million years. The fossil record confirms punctuated equilibrium. Stasis is data. Darwin proposed that all organisms are evolving continuously. This has been proven false. Organisms may change with each new generation ( your face is different than that of your parent) but change is not evolution. Evolution implies change for the better. DNA has evolved for four billion years to resist change – to edit mutation away from its double helix before conception. There is evidence for evolution of plants and animals over the past 3.5 billion years but it has not been continuous and the evidence itself is not at all continuous.

Pathways to speciation are many. During the 1960s bioscientist Lynn Margulis proposed the symbiotic path to species evolution where two different species merge creating a new, more formidable species. When the single-cell energy engine mitochondria merged with other, less energetic single cell organisms three billion years ago many new species of microorganism emerged. When proto-organ systems merged many good things happened within an organism: fluids were synthesized, pumped, filtered, properly timed and the creature remembered where the food lived.  Mergers and acquisitions were ( are?)  a key pathway to speciation. Organisms under great pressure forced to merge with one another in shrinking crowded conditions miles below global ice sheets, speciation occurring next to warm vents from deep within the Earth’s mantle. Population pressure – creatures breaking into one another’s skin and happy with the result. More energy, more motility, more durability, bigger teeth.

Three pathways, of many, to evolution:

  1. Rolling the dice 1,000 times per hour under UV bombardment,  testing new combinations and features against all environments – intracell on up the hierarchy of systems out into the primordial ooze – the Darwin method: mutation followed by natural selection.
  2.  Accidents of fate, genetic drift,  a population disperses throughout the realm, those creatures most remote find themselves on a broken off piece of continent, a new island where they live for eons in isolation from their fellows. Their genes have drifted, initiating evolution of new species. Natural selection was not the primary cause.
  3.  Epigenetics – evolution occurs as DNA, RNA, histones, heritable proteins receive signals between every single cell division among 10 trillion cells throughout a higher organism’s reproductive years. Countless micro-events with evolutionary consequences at each cell division, once a week not at each lifetime. Evolution occurring as each cell divides not as each organism has more fit or less fit offspring. New information re: fitness relayed to the germline: eggs and sperm for inclusion in next year’s model. One thousand trillion evolutionary events per lifetime – not just an array of  random nucleotide mutations passed from parent to child. Non-stop evolutionary feedback-feedforward loops throughout trillions of moments in a single life.

***

JB Questions and observations:

Reading: “Elementary Forms of Religious Life” – Emile Durkheim

  1. Is a television a totem? Does television fill a totemic role in American ( Western) culture?  How about a laptop or an I-phone or a car?
  2. Claude Levi-Strauss patterned his book “the Savage Mind” on Durkheim’s “The Elementary forms of Religious Life”. Both men used the same strategy of assembling published papers in anthropology-social science acting as clearing house for the ideas of many in neat, summaries that became foundational texts.
  3. Types of american totemism within our religion of Capitalism: a.infototems: TV,laptop, I-phone b.Utilitotem; Washer, dryer, range, refrigerator-freezer c. Statustotem: auto, espresso machine
  4. The quark as The God Particle is 100% totemism.
  5. ToDo: Reinstate animal / plant totemism in USA. Assign each animal and plant species in the world to groups of school children investing them with the responsibility to care for their totem organism throughout their lives.
  6. Why would one animal species select another species as a totem?
  7. Note:  Durkheim espousing contextuality in 1912. Contextuality didn’t hit the realm of the built environment ( City planning and architecture) until 1960 in the work of Jane Jacobs. Have architects EVER been on the cutting edge of the ideas of a given era? Not after the era of the Gothic cathedral.
  8. Did the thought of Ruskin and Morris have any direct effect upon Le Corbusier and Mies or was it always filtered through Frank Lloyd wright via the Wasmuth Portfolio? Can one get the full import of an idea second or third hand? That we can, forms the backbone of modern education.
  9. Architecture coughs up its Jencksian history hairball in the mid-1970s lame swerve on hardcore French Postmodernism in the work of Charles Moore, Michael Graves and other pasticheurs of the time. Ughh, such a superficial, desolate and highly publicized dead end for architecture – suckered again.
  10. If snowball Earth had an ice sheet 20 miles thick one billion years ago this must have had an additive effect upon mutational effects of UV radiation as warm pools at top of this high ice were exposed to sunlight at 20 miles up, beyond any filtering atmosphere. Did this high ice push exisitng atmosphere up with it or leave it behind?
  11. JB neologism: “Stochastic Targeting”: to send a barrage of speculative detail. Target mind adjusts this barrage with details known to recipient so it appears that you were 80% correct instead of shooting in the dark.
  12. Can a recessive gene become active during one’s lifespan if the dominant gene fails? How might an activated recessive gene attract RNA polymerase to begin midlife transcription? How does RNA polymerase know which is the dominant gene in the first place?
  13. Sewall Wright gets a lot of credit for adding to our knowledge of evolution as a key generator of the Modern synthesis that combined Darwinism with modern genetics. In retrospect, is this credit deserved?  Was Wright seeing evolution at work with his guinea pigs or observing minor breeding changes?
  14. Our dominant genes are expressed during fetal development affecting sex, height, eye and hair color and many metabolic processes. Do all 46 chromosomes come into play postnatally regarding such things as hormone production and all manner of transcription-translation regulatory process? why not? All 46 chromosomes are part of the chromatin. why would an RNA polymerase not wander over to a recessive gene and put it to work? Especially if the dominant gene was damaged or working inefficiently. Perhaps the distinction between dominant and recessive evaporates after fetal development allowing the environment to call all shots regarding which genes are active among all 40,000 genes not just the human haploid 20,000.
  15. Genetic change has been conflated with, confused with evolution throughout the latter half of the 20th century and the 21st. Calling allele frequency change “evolution” is like calling a grain of pollen a pine tree – well…..it sort of is and sort of isn’t with a 99.9999 % chance that the pollen grain is just another allergen – a sneeze at most. Fisher, Haldane and Sewall Wright explored genetic change. that their theories have been framed as evolution was to jump to conclusions. The core notions of the Modern synthesis are about micro-evolution  – no evolution discernable / provable,  just variation, just change. Variation is not evolution. Discerning pathways of phenotypic change is not discerning pathways of evolution. The Modern Evolutionary Synthesis is not ALL wrong, just ALL too narrow.
  16. Might a bacterium or a virus take a few nucleotides / base pairs from one species of mammal and insert this DNA from mammal One into mammal Two which is a different species from mammal One? Scenario:  Buffalo dying of a viral infection – 50% of his 30 trillion cells have this toxic viral DNA mixed with buffalo DNA in a diseased chromatin soup in 15 trillion cells. A mosquito bites this dying buffalo then it bites a man on his balls infecting a few million germ cells / sperm / gametes with both viral DNA and buffalo DNA, any notable consequences?
  17.  Natural selection does not “cause” evolution any more than an academy award “causes” a fine motion picture or a Nobel Prize “causes” brilliant research. Natural Selection is an outcome not a cause.
  18. Genetic drift explains sports dynasties  – see: Roger Penske and four-wheel genetic drift.
  19. Investigate founder effects on JB “The Ugly Gene” in New England Settlers-17th century Puritans.
  20. Evolutionary biologist Ronald Fisher, a Darwinian gradualist – key player in Modern Evolutionary Synthesis misconstrued the rate,time and degree of the evolution of animal complexity. Fisher was fooled by outward appearances as 90% of vital biochemical pathways were in place before the Cambrian Explosion at 550 million years ago. All else has been biochemical window dressing, couture for bacteria bags: mammals, reptiles, amphibians and birds i.e. experiments in fashion, trivial in scope. Compare the number of microorganisms to the number of multicell organisms on Earth today. Fisher actually believed a bear is different than a snake.
  21. What was the last common ancestor of the chloroplast and the mitochondria?
  22. Test for correlation of high fructose corn sweetener to mitochondrial fission at fat cells and at kidney, hepatic and gut tissue.
  23. Curing a person of cancer is like curing the Earth of humans. what would be an effective strategy?
  1. introduce unfriendly microorganism
  2. add excess heat or cold interrupting metabolism
  3. add dust to interfere with breathing
  4. eliminate food supply
  1. How does one target a single species? what is unique about this cancer family of cells? What is unique about this organism? In humans – the neocortex
  2. At cancer cells  interfere with mitochondrial energy production, dissolve cancer cell membrane, dissolve cancer cell nuclear membrane.
  3. Is the cell outer membrane made of identical lipid bilayer as its nuclear membrane?
  4. Age-old problem: how to direct cancer battle to cancer cell mitochondria only?
  5. Do different tissues have unique mitochondrial DNA? Is liver mito DNA different from that in lungs,heart or kidney?
  6. Review DNA/RNA methylations – differences in various tissue cells. How is a hepatocyte mitochondrial methylation different from a lung cancer cell mitochondria methylation?
  7. To do: Examine 1,000 different cancer cell types to determine differences in their mitochondrial DNA/RNA epigenetic modifications.
  8. This must all be old hat: Target DNA-RNA promoters that are unique at cancer mitochondria to interrupt energy/metabolic process thus killing the cell – starve cancer cells of their glucose.
  9. Do brain tumor cells have unique mitochondria from the brain area tissues of origin. Does each brain area generate unique tumors each with its own signature?
  10. What is the cancer equivalent to the effects of disruption of neocortical function, neocortical links with brainstem, striatum etc. intra-cortical links re: sensory perception. Inter-cortical links re: efferent signaling between neocortex and hypothalamus, thalamus, globus pallidus, putamen, pons, medulla, cerebellum, hippocampus? Cancer-human analogy.
  11. Cancer cure? 24/7 low level ultrasound or uv/infrared light ( something besides traditional radiation-chemo) bombardment geared to upsetting cancer cell mitochondria reproduction i,e, cell division / proliferation. to do: determine quantum level electrical processes/pathways at mitochondria. Halt methylase and or polymerase proliferation.
  12. bio-friendly coated Nano pulsing device inserted into tumor-wireless operation with belt battery pack. Call it the BQMD: Blake Quantum Mitochondrial Disruptor.
  13. Cure cancer by disrupting RER (rough endoplasmic reticulum) adhesion at ribosomes during translation to disrupt lipid production and thus disrupting cell membrane formation. Reverse the hydrophilic property at carcinomal lipid membrane. If there is no hydrophila there will be no cell wall – get to the root.
  14. Cure cancer by control of TOR target –  rapamycin regulation of cell growth. TORC2 regulates cell surface area by influencing lipid production and intracellular turgor. Interrupt TORC2 transcription, translation or transport.
  15. Cure cancer by stopping golgi apparatus from packaging proteins for export to adjacent / daughter cancer cells.
  16. Cure cancer by inhibiting normal cell function at any and or all organelles and all biosynthetic, transcription, translation and lipid production one organelle at a time.. disrupt one-disrupt all. determine the most fundamental metabolite and disrupt it with a wavelength of sound or light.

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January 25, 2015    10:53 am

 

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